A0A5F1B6Q6 · A0A5F1B6Q6_9RICK
- ProteinAconitate hydratase
- GeneacnA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids867 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein.
Catalytic activity
- (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O
Cofactor
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Organic acid metabolism; propanoate degradation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 2-methylisocitrate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | aconitate hydratase activity | |
Molecular Function | iron-responsive element binding | |
Molecular Function | metal ion binding | |
Biological Process | citrate metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAconitate hydratase
- EC number
- Short namesAconitase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Wolbachieae > Wolbachia
Accessions
- Primary accessionA0A5F1B6Q6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 64-541 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: ILANCVKKHINHEISYKPARVLMQDFTGVPAVVDLASMRNYVKKNRGNPSKINPSVPVDLVIDHSVQVDSYGSTSAFGKNVALEVKRNLERYQFLKWGESSFTNFRVVPPGTGICHQVNLEYLAQVVCNDSGVLYPDTLVGTDSHTTMVNGLSVLGWGVGGIEAESVMLGQPISMVIPEVVGFKLIGRLSEGVTATDLVLTITNILRTKGVVGRFVEFYGDGLDCLSLADRATIANMAPEYGATCGFFPIDQKTLDYLNLTGRPKELIKLVEVYAKEQGLWRSNEELAFFDTLKLDLSSVEPVMAGPKRPQDKVFLSQVAESFSKSFSVNESEEGDKLQDGSVVIAAITSCTNTSNPSVMIAAGLVARNAVNLGLKSKPWVKTSLAPGSQVVTEYLEKSGLQEDLNALGFNLVGYGCTTCIGNSGPLNEDIESDIKDKNLTVAAVLSGNRNFEGRIHPLVKANYLASPPLVVVYVLAG | ||||||
Domain | 673-799 | Aconitase A/isopropylmalate dehydratase small subunit swivel | ||||
Sequence: IYLKGFGVEPQDFNSYGSRRGNHNVMMRGTFANIRIRNKMVSAEGGYTKHIPSQETMSIFDAAMQYKREAVPLVVIAGKEYGTGSSRDWAAKGTALLGIKAVIAESFERIHRSNLVGMGVLPLAFQD |
Sequence similarities
Belongs to the aconitase/IPM isomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length867
- Mass (Da)94,872
- Last updated2019-11-13 v1
- ChecksumD9E4FD1A031642AB