A0A5F1B6Q6 · A0A5F1B6Q6_9RICK

Function

function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Organic acid metabolism; propanoate degradation.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function2-methylisocitrate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionaconitate hydratase activity
Molecular Functioniron-responsive element binding
Molecular Functionmetal ion binding
Biological Processcitrate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aconitate hydratase
  • EC number
  • Short names
    Aconitase

Gene names

    • Name
      acnA
    • ORF names
      E5C28_03725

Organism names

Accessions

  • Primary accession
    A0A5F1B6Q6

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain64-541Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Domain673-799Aconitase A/isopropylmalate dehydratase small subunit swivel

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    867
  • Mass (Da)
    94,872
  • Last updated
    2019-11-13 v1
  • Checksum
    D9E4FD1A031642AB
MNNSLNAKTTLNIDGRLYNYFNLSNAGKFLGVNLTKLPCSLKVLLENLLRNEDGVSVKLDDIKILANCVKKHINHEISYKPARVLMQDFTGVPAVVDLASMRNYVKKNRGNPSKINPSVPVDLVIDHSVQVDSYGSTSAFGKNVALEVKRNLERYQFLKWGESSFTNFRVVPPGTGICHQVNLEYLAQVVCNDSGVLYPDTLVGTDSHTTMVNGLSVLGWGVGGIEAESVMLGQPISMVIPEVVGFKLIGRLSEGVTATDLVLTITNILRTKGVVGRFVEFYGDGLDCLSLADRATIANMAPEYGATCGFFPIDQKTLDYLNLTGRPKELIKLVEVYAKEQGLWRSNEELAFFDTLKLDLSSVEPVMAGPKRPQDKVFLSQVAESFSKSFSVNESEEGDKLQDGSVVIAAITSCTNTSNPSVMIAAGLVARNAVNLGLKSKPWVKTSLAPGSQVVTEYLEKSGLQEDLNALGFNLVGYGCTTCIGNSGPLNEDIESDIKDKNLTVAAVLSGNRNFEGRIHPLVKANYLASPPLVVVYVLAGTVQIDLTKDPICKDKNGSDVYLKDIWPTNNEVESCVKSVVTREMFIQKYKDVFSGDEHWQKIKCEKSEIYDWDAKSTYIQNPPYFDNLSTKNNKSNIVDIKNAQILAMFGDSVTTDHISPAGNIALNSPAGIYLKGFGVEPQDFNSYGSRRGNHNVMMRGTFANIRIRNKMVSAEGGYTKHIPSQETMSIFDAAMQYKREAVPLVVIAGKEYGTGSSRDWAAKGTALLGIKAVIAESFERIHRSNLVGMGVLPLAFQDGVTRKIFDSSEIVSIKGEVVPNGNLECIIKRKDDSEQSIQLKCCVQTATEVKYLMSGGVLSYILAQSF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SRKC01000031
EMBL· GenBank· DDBJ
TGB06416.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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