A0A5E5RBC0 · A0A5E5RBC0_PSEAI
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids231 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- H+ + orotidine 5'-phosphate = CO2 + UMP
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13 | substrate | ||||
Sequence: D | ||||||
Binding site | 35 | substrate | ||||
Sequence: K | ||||||
Binding site | 62-71 | substrate | ||||
Sequence: DLKFHDIPNT | ||||||
Active site | 64 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 122 | substrate | ||||
Sequence: T | ||||||
Binding site | 182 | substrate | ||||
Sequence: R | ||||||
Binding site | 190 | substrate | ||||
Sequence: Q | ||||||
Binding site | 210 | substrate | ||||
Sequence: G | ||||||
Binding site | 211 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A5E5RBC0
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-226 | Orotidine 5'-phosphate decarboxylase | ||||
Sequence: PIIVALDFPTREAALALADQLDPKLCRVKVGKELFTSCAAGIVETLRGKGFEVFLDLKFHDIPNTTAMAVKAAAEMGVWMVNVHCSGGLRMMAACRETLEAFSGPRPLLIGVTVLTSMEREDLAGIGLDIEPQEQVLRLAALAQKAGMDGLVCSAQEAPALKAAHPGLQLVTPGIRPRQRQDDQRRILTPRQALDAGSDYLVIGRPISQAADPAKALAAI |
Sequence similarities
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length231
- Mass (Da)24,549
- Last updated2019-11-13 v1
- ChecksumF7D20F9988B253E9