A0A5E5QXT6 · A0A5E5QXT6_PSEAI

Function

function

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site18GTP (UniProtKB | ChEBI)
Binding site25[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site29[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site31S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site32[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site67GTP (UniProtKB | ChEBI)
Binding site71S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site98GTP (UniProtKB | ChEBI)
Binding site122S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site159GTP (UniProtKB | ChEBI)
Binding site193S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site257[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site260[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site262-264GTP (UniProtKB | ChEBI)
Binding site274[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionGTP 3',8'-cyclase activity
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological ProcessMo-molybdopterin cofactor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP 3',8-cyclase
  • EC number
  • Alternative names
    • Molybdenum cofactor biosynthesis protein A

Gene names

    • Name
      moaA_2
    • Synonyms
      moaA
    • ORF names
      TUEID40_01103

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ID40
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A5E5QXT6

Interaction

Subunit

Monomer and homodimer.

Family & Domains

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    331
  • Mass (Da)
    37,213
  • Last updated
    2019-11-13 v1
  • Checksum
    379A1B6922978633
MSDSRLVDPFGRRITYLRLSVTDRCDFRCTYCMSEDMQFLPRDQVLSLEELYAVADAFIGLGVRRIRITGGEPLVRKGITGLLARLGQRAELEDLAITTNGSQLRERAAELKAAGVRRLNVSLDSLQRERFAAFTRSDRLEQVLDGIQAAREAGFERIKLNCVVQKGRNDDEILNLVEYALANQLDISFIEEMPLGSITSHRRELTLCTSDEVRAIIERRWPLTPSLARSGGPSRYYQIGDEPSRIGFISPHSNNFCGDCNRVRVTAEGKLVLCLGHEGALDLRELLRSHPGDRERLSAALVAALNLKPERHHFDAQEQVQVLRFMSMTGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR700248
EMBL· GenBank· DDBJ
VVH79949.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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