A0A5E4DMZ9 · A0A5E4DMZ9_HUMAN
- ProteinIntegrin beta
- GeneITGB3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids788 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | integrin complex | |
Molecular Function | metal ion binding | |
Biological Process | cell adhesion | |
Biological Process | integrin-mediated signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameIntegrin beta
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A5E4DMZ9
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 719-741 | Helical | ||||
Sequence: ILVVLLSVMGAILLIGLAALLIW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MRARPRPRPLWATVLALGALAGVGVG | ||||||
Chain | PRO_5023035324 | 27-788 | Integrin beta | |||
Sequence: GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKKCVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT | ||||||
Disulfide bond | 31↔461 | |||||
Sequence: CTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDC | ||||||
Disulfide bond | 39↔49 | |||||
Sequence: CQQCLAVSPMC | ||||||
Disulfide bond | 42↔75 | |||||
Sequence: CLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNC | ||||||
Disulfide bond | 52↔64 | |||||
Sequence: CSDEALPLGSPRC | ||||||
Disulfide bond | 203↔210 | |||||
Sequence: CYDMKTTC | ||||||
Disulfide bond | 258↔299 | |||||
Sequence: CDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQC | ||||||
Disulfide bond | 400↔412 | |||||
Sequence: CLNNEVIPGLKSC | ||||||
Disulfide bond | 432↔681 | |||||
Sequence: CPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKKCVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNC | ||||||
Disulfide bond | 459↔463 | |||||
Sequence: CDCAC | ||||||
Disulfide bond | 474↔486 | |||||
Sequence: CNNGNGTFECGVC | ||||||
Disulfide bond | 483↔521 | |||||
Sequence: CGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVC | ||||||
Disulfide bond | 488↔497 | |||||
Sequence: CGPGWLGSQC | ||||||
Disulfide bond | 499↔512 | |||||
Sequence: CSEEDYRPSQQDEC | ||||||
Disulfide bond | 527↔532 | |||||
Sequence: CLCGQC | ||||||
Disulfide bond | 529↔562 | |||||
Sequence: CGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMC | ||||||
Disulfide bond | 534↔547 | |||||
Sequence: CHSSDFGKITGKYC | ||||||
Disulfide bond | 549↔554 | |||||
Sequence: CDDFSC | ||||||
Disulfide bond | 568↔573 | |||||
Sequence: CSCGDC | ||||||
Disulfide bond | 570↔601 | |||||
Sequence: CGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLC | ||||||
Disulfide bond | 575↔584 | |||||
Sequence: CDSDWTGYYC | ||||||
Disulfide bond | 586↔593 | |||||
Sequence: CTTRTDTC | ||||||
Disulfide bond | 607↔612 | |||||
Sequence: CECGSC | ||||||
Disulfide bond | 609↔657 | |||||
Sequence: CGSCVCIQPGSYGDTCEKCPTCPDACTFKKKCVECKKFDRGALHDENTC | ||||||
Disulfide bond | 614↔624 | |||||
Sequence: CIQPGSYGDTC | ||||||
Disulfide bond | 627↔630 | |||||
Sequence: CPTC | ||||||
Disulfide bond | 634↔643 | |||||
Sequence: CTFKKKCVEC | ||||||
Disulfide bond | 640↔713 | |||||
Sequence: CVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPEC | ||||||
Disulfide bond | 661↔689 | |||||
Sequence: CRDEIESVKELKDTGKDAVNCTYKNEDDC |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 30-76 | PSI | ||||
Sequence: ICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCA | ||||||
Domain | 38-461 | Integrin beta subunit VWA | ||||
Sequence: SCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDC | ||||||
Domain | 634-718 | Integrin beta subunit tail | ||||
Sequence: CTFKKKCVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPD | ||||||
Domain | 742-788 | Integrin beta subunit cytoplasmic | ||||
Sequence: KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT |
Sequence similarities
Belongs to the integrin beta chain family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length788
- Mass (Da)87,057
- Last updated2019-11-13 v1
- ChecksumF2A86238E80ABFDA