A0A5D6SY06 · A0A5D6SY06_KLEPN
- ProteinFatty acid oxidation complex subunit alpha
- GenefadJ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids714 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
Catalytic activity
- (3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 118 | Important for catalytic activity | |||
Site | 140 | Important for catalytic activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | 3-hydroxybutyryl-CoA epimerase activity | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid oxidation complex subunit alpha
Including 2 domains:
- Recommended nameEnoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase
- EC number
- Recommended name3-hydroxyacyl-CoA dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A5D6SY06
Proteomes
Subcellular Location
Interaction
Subunit
Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-190 | Enoyl-CoA hydratase | |||
Region | 306-714 | 3-hydroxyacyl-CoA dehydrogenase | |||
Domain | 310-489 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | |||
Domain | 492-586 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | |||
Domain | 619-703 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | |||
Sequence similarities
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length714
- Mass (Da)77,373
- Last updated2020-02-26 v1
- Checksum8BA44AEDCBDC96F6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAAKYD010000006 EMBL· GenBank· DDBJ | NGN72047.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NCMJ01000021 EMBL· GenBank· DDBJ | PLE29056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKGE01000007 EMBL· GenBank· DDBJ | SXN30887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKUT01000003 EMBL· GenBank· DDBJ | SYH31009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULCI01000008 EMBL· GenBank· DDBJ | SYR38319.1 EMBL· GenBank· DDBJ | Genomic DNA |