A0A5D6SY06 · A0A5D6SY06_KLEPN

  • Protein
    Fatty acid oxidation complex subunit alpha
  • Gene
    fadJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for site.

TypeIDPosition(s)Description
Site118Important for catalytic activity
Site140Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular Function3-hydroxybutyryl-CoA epimerase activity
Molecular Functionenoyl-CoA hydratase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fatty acid oxidation complex subunit alpha

Including 2 domains:

  • Recommended name
    Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase
  • EC number
  • Recommended name
    3-hydroxyacyl-CoA dehydrogenase
  • EC number

Gene names

    • Name
      fadJ
    • ORF names
      B6I68_03715
      , G4V31_07855
      , SAMEA3499901_01899
      , SAMEA3515122_01894
      , SAMEA3538828_02279

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 2429
    • COL-Kpn30
    • EuSCAPE_AT029
    • EuSCAPE_HU047
    • EuSCAPE_IT093
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A5D6SY06

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-190Enoyl-CoA hydratase
Region306-7143-hydroxyacyl-CoA dehydrogenase
Domain310-4893-hydroxyacyl-CoA dehydrogenase NAD binding
Domain492-5863-hydroxyacyl-CoA dehydrogenase C-terminal
Domain619-7033-hydroxyacyl-CoA dehydrogenase C-terminal

Sequence similarities

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    714
  • Mass (Da)
    77,373
  • Last updated
    2020-02-26 v1
  • Checksum
    8BA44AEDCBDC96F6
MDTVSAFKLEVRADKIAVITIDAPGEKMNTLKAEFGSQVRGLIRQLRDDKSVRGVVFISAKADNFIAGADINMIARCRSAQEAEALARQGQQIMAEIHGLPIPVIAAIHGACLGGGLELALACHGRICSDDEKTRLGLPEVQLGLLPGSGGTQRLPRLIGVSTALDMMLTGKQLRPRQALKAGLVDEVVPQAILLQAAVELALKGRPTSREVSVRERVLAGPLGRHLLFQFVGKQTQRKTQGNYPAVKRILQVVENGLAHGCSSGYAEEARAFGELAMSPQSQALRSIFFASTDLKKDPGAEAGPGPLRSVAVLGGGLMGGGIAYVTACKGGLPVRIKDIQPRGINHALKYSWDLLNKQVRQRRLRPVERDRQMALISGTTDYQGFAHRDVVIEAVFEDLALKQRMVSEVEQYGGPQTIFASNTSSLPIGDIAAHASRPGQVIGLHFFSPVEKMPLVEVIPHKGTDPQTIATVVQLAKRQGKTPIVVADKAGFYVNRILAPYINEAMRLLVEGEPIEVIDNALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEGAFGERFSPPANIIDAILKDDRKGRKNNRGFYLYETKGRKSKKRPDPAVYPLLGIGRPQSRLSAQQVAERCVMMMLNEAARCFDEQIIRSARDGDIGAVFGIGFPPFLGGPFRYMDTIGAGEVAAILQRLAAQFGPRFTPCDTLLRMAEQGTTFWPADERLT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAKYD010000006
EMBL· GenBank· DDBJ
NGN72047.1
EMBL· GenBank· DDBJ
Genomic DNA
NCMJ01000021
EMBL· GenBank· DDBJ
PLE29056.1
EMBL· GenBank· DDBJ
Genomic DNA
UKGE01000007
EMBL· GenBank· DDBJ
SXN30887.1
EMBL· GenBank· DDBJ
Genomic DNA
UKUT01000003
EMBL· GenBank· DDBJ
SYH31009.1
EMBL· GenBank· DDBJ
Genomic DNA
ULCI01000008
EMBL· GenBank· DDBJ
SYR38319.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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