A0A5D0RZZ3 · A0A5D0RZZ3_9RHOB

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-19substrate
Active site75Proton acceptor
Binding site75Mg2+ (UniProtKB | ChEBI)
Binding site76substrate
Binding site161-164substrate
Binding site184substrate
Binding site189-190substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      FQ320_16975

Organism names

  • Taxonomic identifier
  • Strain
    • ACAM 378
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Oceaniovalibus

Accessions

  • Primary accession
    A0A5D0RZZ3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    22,117
  • Last updated
    2019-11-13 v1
  • Checksum
    5AB0ED7E1AFD2F68
MTRRFSGERLLIATHNAGKLEEIADLLRPFSVAVVSAGELGLPEPIEDGTTFVENARTKAHAAAKASGLIALSDDSGIEIDALDGAPGVYTADWAETPQGRDFTMAMSRTHDKLEAANAPHPRTARFCCTLVMAWPDGHDEVFPGVMPGQVVWPMRGEQGHGYDPIFMPDGYNITFGEMDRMEKNRISHRADAFRKLVAGCFA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VSJK01000012
EMBL· GenBank· DDBJ
TYB86425.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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