A0A5C8WIQ7 · A0A5C8WIQ7_9HYPH

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      FV230_04815

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WL6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylobacterium

Accessions

  • Primary accession
    A0A5C8WIQ7

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-53Helical
Transmembrane73-95Helical
Transmembrane104-121Helical
Transmembrane127-149Helical
Transmembrane156-175Helical
Transmembrane195-215Helical
Transmembrane248-269Helical
Transmembrane289-306Helical
Transmembrane315-335Helical
Transmembrane341-360Helical
Transmembrane372-392Helical
Transmembrane412-430Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-435Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    456
  • Mass (Da)
    47,682
  • Last updated
    2019-11-13 v1
  • MD5 Checksum
    E1BC49627A906E9EEB119EE99A5A155D
MVDAAIAKGDPKDLSVALPAGGRSDPSPPAELKLLFLLSWVLCAVFYFFQYAVRSAPGVMQAELTSAWGANHIGTMISAYYVAYAVMALVAGVLLDRYGAHRTIPYGIAVVGLGCLVFAQGSEAAGMIGFVLQATGAIFAFVGSSYVAARYLPTRMLALFIGLTQCLGMAGAAFGSKPVHMAIDPAGGFNVPWQHVWVTFAAMGFVLALATWFVMPRETGDSPSHHAEFSVSALLHPFKVIFGNPQSWLAGIVGGLLFLPTTIGALVWATSFLHAGENLSMADAASDAAMVPIGWVLGCPLLGYVSDRLGRRKPVLLGGALLMLAAGLTAIYVPVGTLPRYSVALVLGIASGAAMIPFSMMKETNPSEVKGTAAGVMNFLVFVTTGIMSPFISHLMQPRQGVPLTLADFQTAFLPLVGGVVLALVLALFLRETGTAEQGPLAQDGTKPFVSVLAPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VRVH01000018
EMBL· GenBank· DDBJ
TXN72456.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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