A0A5C8W7I3 · A0A5C8W7I3_9HYPH

Function

function

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site11Nucleophile
Binding site11Mg2+ (UniProtKB | ChEBI)
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site173Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionphosphoglycolate phosphatase activity
Biological Processcarbohydrate metabolic process
Biological Processdephosphorylation
Biological ProcessDNA repair
Biological Processglycolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoglycolate phosphatase
  • EC number
  • Short names
    PGP
    ; PGPase

Gene names

    • Name
      gph
    • ORF names
      FV230_24825

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WL6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylobacterium

Accessions

  • Primary accession
    A0A5C8W7I3

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    24,111
  • Last updated
    2019-11-13 v1
  • MD5 Checksum
    C1D395531CE33656AD9E14DBA924FC9A
MPTLPKIAVFDLDGTLAETAGDLVGTLNVLLVREGLPELALEEARDLIGAGAKALIRRGFEAAGRELTPERHEALFGDFLEHYGAHLCERSHLYPGVVEALDRLEAEGFRLAVCTNKVEGLAVDLLDQLGIGGRFAAICGRATFPYSKPDPRHITLTIARAGGDRERAVMVGDSRADIDAAKAAGIPVVAVTFGYTDTPVDQLGPDRVISHFSDLPGAVAELMSAQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VRVH01000332
EMBL· GenBank· DDBJ
TXN60998.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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