A0A5C7EQV2 · A0A5C7EQV2_9ACTN

Function

function

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site223Zn2+ (UniProtKB | ChEBI)
Binding site288Zn2+ (UniProtKB | ChEBI)
Binding site289Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethionine synthase activity
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine synthase
  • EC number
  • Alternative names
    • 5-methyltetrahydrofolate--homocysteine methyltransferase

Gene names

    • ORF names
      E4J93_05625

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BA40
  • Taxonomic lineage
    Bacteria > Actinomycetota > Coriobacteriia > Coriobacteriales > Coriobacteriaceae > Collinsella

Accessions

  • Primary accession
    A0A5C7EQV2

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-303Hcy-binding
Domain335-579Pterin-binding
Domain617-710B12-binding N-terminal
Domain710-831B12-binding

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    831
  • Mass (Da)
    86,966
  • Last updated
    2019-11-13 v1
  • Checksum
    9EECAC99D97DD223
MPTYAHHVPAAPRTLDSIRIADADLRAALEGRRHLLFDGGMGTMLQAAGLAAGALPELLCLSDPDAITRIHAAYVAAGSEVVTTNTFGANALKLDGRAEVEEVYQAATACARAAGARYVAGDIGPLGALLRPLGTMSFDEAYGQFARCARAAADAGCDLIVIETMTDLAEIKAAVLAAKDVCDLPIFATMTFEADGRTFLGTSPAIAAVTLDALGVEVLGINCSLGPSELRPFARDMLAATAKPVMVQANAGLPHIEDGCTVFDIGPDAYRDDVAAMVADGVGIIGGCCGTDPRHIEQLARIIAGRAPEPRRAPGSLTVTSAQGLVELPAEGRRIAVIGERINPTGKKRLQAALREGSIDYVVGQGISQQEQGADILDVNVGLPGLDEPALIARAVEALQGATLLPLQIDSTDVRAIEAGVRAYAGKPIINSVNGSREALDAVLPLAAHYGCNVIGLTLDEDGIPATAEGRIAIARRIIDEAARYGIGRDRILIDCLVMTASTNQQQVGQILDAVARCRAELGVHCALGVSNVSFGLPARSLLNSTFLAAAFGAGLDAPIMNPGSARYMDTVRSYRVLNGEDDGSGAYIERYATWSDPYTTPAGASIEAPGAGAPDAPIAPGSQSPVEELHHLVLTGRKADVPARVRQLLAGYGALDIIDHMLIPALDEVGERFDRGTFFLPQLMASAEAARAGFDTIRDAMPAGDVADKGRIALATVKGDIHDIGKNIVKMLLENYGYHVFDLGRDVDPLAVLDAVRTHDIPLVGLSALMTTTVASMEETIAILRREAPGVRVFVGGAVLTPEYAQQIGADFYAKDAAESARIAERVFSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VOWY01000011
EMBL· GenBank· DDBJ
TXF36255.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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