A0A5C7EQR4 · A0A5C7EQR4_9ACTN

  • Protein
    Ribose-phosphate pyrophosphokinase
  • Gene
    prs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site49-51ATP (UniProtKB | ChEBI)
Binding site109-110ATP (UniProtKB | ChEBI)
Binding site143Mg2+ (UniProtKB | ChEBI)
Binding site184Mg2+ (UniProtKB | ChEBI)
Active site207
Binding site209D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site233D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site237-241D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processpurine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      E4J93_01395

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BA40
  • Taxonomic lineage
    Bacteria > Actinomycetota > Coriobacteriia > Coriobacteriales > Coriobacteriaceae > Collinsella

Accessions

  • Primary accession
    A0A5C7EQR4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-133Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    35,060
  • Last updated
    2019-11-13 v1
  • Checksum
    C87C279304FC4648
MPTTDPKKTVDMNKILRVYSGSSNRPLAEKIAGLLGVELSGLTLKQFANGEIYARYDETVRGADVFLIQSVAGANVNDMLMELLIATDAAKRASARSITAVITHYGYARQDRKAGPREPITARLVANLLECAGVDRIITLDLHQGQIQGFFDIPVNHLSALPLFADYYDAMGFDTDNLVVVSPDVGRAKAAKKLSDMLGCSLAIAHKGRPRHNAAEVMGIIGDIKGKTCIINDDMIDTAGTLCANVKELKALGAGDIYVCATHGIFSGPAIERLNDAPIVECVVTDAIPVEETGKIKTISVAGEFAETIKAVYHERSVSTLVGGDFAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VOWY01000002
EMBL· GenBank· DDBJ
TXF38555.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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