A0A5C7EQ62 · A0A5C7EQ62_9ACTN
- ProteinTyrosine--tRNA ligase
- GenetyrS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids397 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity
- ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H+ + L-tyrosyl-tRNA(Tyr)
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | RNA binding | |
Molecular Function | tyrosine-tRNA ligase activity | |
Biological Process | tyrosyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Coriobacteriia > Coriobacteriales > Coriobacteriaceae > Collinsella
Accessions
- Primary accessionA0A5C7EQ62
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 35-44 | 'HIGH' region | ||||
Sequence: PTSPDLHLGH | ||||||
Motif | 219-223 | 'KMSKS' region | ||||
Sequence: KMSKS | ||||||
Domain | 339-375 | RNA-binding S4 | ||||
Sequence: LLKDAGLAPSAGEARRLIDGGGVKIDGEAVAPKSYNI |
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length397
- Mass (Da)43,358
- Last updated2019-11-13 v1
- ChecksumFAA75E819BE3484B
Keywords
- Technical term