A0A5C6PTN8 · A0A5C6PTN8_9TELE
- ProteinFatty acid synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2524 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
Catalytic activity
- (2E)-butenoyl-[ACP] + NADPH + H+ = butanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-decenoyl-[ACP] + NADPH + H+ = decanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-dodecenoyl-[ACP] + NADPH + H+ = dodecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-hexadecenoyl-[ACP] + NADPH + H+ = hexadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-hexenoyl-[ACP] + NADPH + H+ = hexanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-octadecenoyl-[ACP] + NADPH + H+ = octadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-octenoyl-[ACP] + NADPH + H+ = octanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (2E)-tetradecenoyl-[ACP] + NADPH + H+ = tetradecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- (3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- (3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2OThis reaction proceeds in the forward direction.
- 3-oxobutanoyl-[ACP] + NADPH + H+ = (3R)-hydroxybutanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxodecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxydecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxododecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxydodecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxohexadecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyhexadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxohexanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyhexanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxooctadecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyoctadecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxooctanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyoctanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- 3-oxotetradecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxytetradecanoyl-[ACP] + NADP+This reaction proceeds in the forward direction.
- hexadecanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- hexanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- octanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- tetradecanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- acetyl-[ACP] + malonyl-[ACP] + H+ = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- butanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- decanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
- dodecanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2This reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 889 | Proton acceptor; for dehydratase activity | ||||
Sequence: H | ||||||
Active site | 1045 | Proton donor; for dehydratase activity | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | [acyl-carrier-protein] S-acetyltransferase activity | |
Molecular Function | [acyl-carrier-protein] S-malonyltransferase activity | |
Molecular Function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity | |
Molecular Function | fatty acid synthase activity | |
Molecular Function | fatty acyl-[ACP] hydrolase activity | |
Molecular Function | phosphopantetheine binding | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid synthase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Tetraodontiformes > Tetradontoidea > Tetraodontidae > Takifugu
Accessions
- Primary accessionA0A5C6PTN8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-416 | Ketosynthase family 3 (KS3) | ||||
Sequence: MDEVVIAGISGRLPESNNLEEFWENLINGVDMVTEDDRRWKPGLYGLPKRNGKLKDISHFDAAFFGVHSKQANTMDPQLRLMMEVAYEAIIDGGLNPAAMRGSKTGVYIGVSGSEAAEAFSRDPEELLGYSMTGCQHAMLANRLSYFFDFTGPSTSIDTACSSSLLALENAFHAIRHGQCDAALVGGVNLLLKPNTSVQFMKLGMLSPEGTCQSFDSSGNGYCRSEAAVAVLLTKKSVAKRVYATVLNAGNNTDGYKEQGVTFPSGKMQQRLVRSLYQEANISPEEVEYIEAHGTGTKVGDPQEVNGIVSVFCQSKRDPLLMGSTKSNMGHPEPASGLAAMAKVLLSLERGVWAPNLHFSSPNPDIPALTDGRVQVVDKPIPVRGGIVGVNSFGFGGSNVHVILRP | ||||||
Region | 855-978 | N-terminal hotdog fold | ||||
Sequence: PKVEDFPTSSGGSGSATIYNIDTSPESSDNYLIGHCIDGRVLYPATGYLVLAWRTLVRNMGVVMETTPVTFENVTIHRATILPKTGSFQLEVRLMLATNTFEISENGNLAVSGKVNILEDTNLS | ||||||
Domain | 855-1122 | PKS/mFAS DH | ||||
Sequence: PKVEDFPTSSGGSGSATIYNIDTSPESSDNYLIGHCIDGRVLYPATGYLVLAWRTLVRNMGVVMETTPVTFENVTIHRATILPKTGSFQLEVRLMLATNTFEISENGNLAVSGKVNILEDTNLSSFHHQINQPVAHDGENPKMKLTASEIYKELRLRGYDYGKTFQGILESNHAGDKGKLHWTGNWVTFLDTMLQMLVVGLSGRSLRLPTRIRTVCIDPVVHLQKICKYTDEKQAMDVYINRCLDNIVAGGVQISGLHATVAPRRQQL | ||||||
Region | 996-1122 | C-terminal hotdog fold | ||||
Sequence: KMKLTASEIYKELRLRGYDYGKTFQGILESNHAGDKGKLHWTGNWVTFLDTMLQMLVVGLSGRSLRLPTRIRTVCIDPVVHLQKICKYTDEKQAMDVYINRCLDNIVAGGVQISGLHATVAPRRQQL | ||||||
Domain | 2134-2214 | Carrier | ||||
Sequence: RSEAGSQRNLVDAVAHILGVRDVNNLNADSSLADLGLDSLMGVEIRQILERDYDIVMAMREIRQLTINKLREMVNSKPEGA |
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,524
- Mass (Da)275,948
- Last updated2019-11-13 v1
- ChecksumDF2A306A1EF95B44
Keywords
- Technical term