A0A5C6G2L7 · A0A5C6G2L7_9HYPO

  • Protein
    NAD(P)H-hydrate epimerase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site61-65(6S)-NADPHX (UniProtKB | ChEBI)
Binding site62K+ (UniProtKB | ChEBI)
Binding site123K+ (UniProtKB | ChEBI)
Binding site127-133(6S)-NADPHX (UniProtKB | ChEBI)
Binding site156(6S)-NADPHX (UniProtKB | ChEBI)
Binding site159K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Molecular Functionnucleotide binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • ORF names
      ED733_001309

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Cep018-CH2
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium

Accessions

  • Primary accession
    A0A5C6G2L7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-217YjeF N-terminal

Sequence similarities

Belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    236
  • Mass (Da)
    25,810
  • Last updated
    2019-11-13 v1
  • Checksum
    BD33EB20E6873BFE
MALKTLGAKAATALDQELMSTCAFSIDQLMELAGLSVSQAVYRVHPLEKGRRILIACGPGNNGGDGLVAARHLFYYGYQPRIYYPKRGKNELYERLAKQLEDLEIPFVDDFQSAAISTDHIVDAIFGFSFSGDVREPFPKVIHALEETKVPVTSVDAPSSWNIETGPPKSGLGSAFMPTALVSLTAPKPLVKFFKGRHFVGGRFVSPSIAKKYDFEIPEYPGVDQIVEVPTTNGKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SBHS01000043
EMBL· GenBank· DDBJ
TWU71489.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help