A0A5B9FYZ1 · A0A5B9FYZ1_9POTV

Function

function

Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.

Catalytic activity

  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
    EC:3.4.22.45 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

128332004006008001,0001,2001,4001,6001,8002,0002,2002,4002,6002,800
TypeIDPosition(s)Description
Active site579For helper component proteinase activity
Active site656For helper component proteinase activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasmic vesicle
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentviral capsid
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionstructural molecule activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SCMVBMT
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Stelpaviricetes > Patatavirales > Potyviridae > Potyvirus

Accessions

  • Primary accession
    A0A5B9FYZ1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane955-977Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with host eIF4E protein (via cap-binding region); this interaction mediates the translation of the VPg-viral RNA conjugates (By similarity).
Part of a complex that comprises VPg, RNA, host EIF4E and EIF4G; this interaction mediates the translation of the VPg-viral RNA conjugates

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain99-233Peptidase S30
Domain571-697Peptidase C6
Domain1186-1338Helicase ATP-binding
Domain1357-1516Helicase C-terminal
Domain1992-2210Peptidase C4
Domain2476-2600RdRp catalytic
Region2754-2833Disordered
Compositional bias2773-2833Polar residues

Sequence similarities

Belongs to the potyviridae genome polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    2,833
  • Mass (Da)
    319,922
  • Last updated
    2019-11-13 v1
  • Checksum
    04FEA75D702CEC39
MAGSWTHVSYKWQPNVNNDRDVRKVMEMFAAKHQHYTEEQRLAHNSKLLRKAYVVDVEPVKPAPEPIRRKVWVEKFDHNPTEDLVYPRLVTVKKAAEMKPVNTSINKLIRDVLDISKGSSLKLELIGKRQKCRTQLAIKKYNNKDYLHCRTRHEDNMFKRRDVAIGIEWIPTIEAIARCYSTVNKQEMQSLYKGSSGLTFMQNDELFIVRGRMNGELVNSLEENKNVLDIDHYADPQANDFWKGYTDAYVANRSISTTHTVHTPTINLVECGKRMALLEILFHSTFKITCKTCNIDDLELSDDEFGAKLFKNLQRIEEQQREYLAKDQKLRRMIQFIKERCNPKFSHLPLLWQVAETIGHYTDNQSKQIIDISEALIKVNTLTPDDAVKASVALLEVARWYKNRKESLKTDTLDSFRNKISPKSTINTALMCDNQLDKNANFVWGNREYHAKRFFSNYFEAVDPTDAYEKHVTRFNPNGQRKLSIGKLVIPLDFQKIRDSFVGLAINKQPLTKACVSKIDGGYVYPCCCVTTEFGKPAYSEIIPPTKGHITIGNSVDPKIVDLPNTTPPSMYIAKDGYCYINIFLAAMINVNEDSAKDYTKFLRDELVERLGKWXXXXXXLKDVATACYALSVMFPEIKNAELPPILVDHESKSMHVIDSYGSLSVGFHILKASTVGQLIKFQYESMDSEMREYIVGGTLTTQTFNKLLTSLAKNMFKPDQIKQMIEEEPFLLMMAIASPTMLIALYNNCYIEQAMTYWIVKNQGVAAIFAQLEALAKKTSQAELLVQQMQILEKASNQLRLAVTGLNHVDPAKRLLWSHLEAMTTRSEMNKELIAEGYALYDERLYALMEKSYVDQLNQSWAELSFCGKFSAIWRVFKVKKYYKPSLTVRKSVDLGAVYNISATHLISDLAQRSRDRASSILTKLRNGFYDKVEKARTRAIKTVYWFIPDIFRLMHIFIVLSLLTTVANTIIVTMNDYKKLKKQQREDEYEAEINEVRKIHANLMKEHNDNLTCEQFIEHMRQTHPRLIEATLELTHTGVIHEGKSNLETNLEQAMAVGTLLTMMLDPQKSDAVYKVLNKMRTVISTFEQNVPFPSINFTNILTPSVAQQSVDVDEPLTLSTDKNLTIDFDTNQDLPADTFSNDVTFEDWWANQISNNRTVPHYRLGGKFVEFTRENAAHVSIELAHSNLEKEFLLRGAVGSGKSTGLPYHLSMRGKVLLIEPTRPLAENVCRQLQGPPFNVSPTLQMRGLSSFGCTPITIMTSGFALHMYANNPDKISDYDFIIFDECHIMEAPAMAFYCLLKEYEYRGKIIKVSATPPGRECEFSTQHPVDIHVCENLTQQQFVRELGSGSNVDATKYGNNILVYVASYNDVDSLAHALTELHYSVIKVDGRTMKQNTTGIVTNGTSQKKCFVVATNIIENGVTLDVDVVVDFGLKVTAELDVDNRAILYKRVSISYGERIQRLGRVGRNKPGTVVRIGKTMKGLQEIPAMIATEAAFMCFAYGLKVITHNVSTTHLAKCTVKQARTMMQFEISPFVMAELVKFDGSMHPQIHETLVKYKLRDSVIMLRPNAIPKVNFHNWLTARDYNRIGCSLELEDHVKIPYYIRGVPDKLYGKLYDIILQYSPTSCYGRLSSACAGKVAYTLRTDPCSLPRTIAIINALITEEYAKRDHYRNMIANPSSSHAFSLNGLVSMIASRYMKDHTKENIDKLIKVRDQLLEFQGMGMQFQDPSELMDIGALNTVIHQGMDATAACIGLQGRWNASLIQRDLMIAGGVFIGGILMMWSLFTKWGTTNVSHQGKNKRSRQKLKFKQARDTKYAYDVTGSEETLGENFGTAYTKKGKGKGTKVGLGVKQHKFHMMYGFDPQEYNLIRFVDPLTGATLDEQIHADIRLVQEHFDIIREEAVANDTIERQHIYGNPGLQAFFIQNGSANALRVDLTPHSPLRVMTNNNIAGFPEYEGTLRQTGTALTVPVNQVPAANETGVAHESKSMMAGLGDYTPISQQLCLVQNDSEGVKRNVYAIGYGSYLISPAHLFKYNNGEITIKSSRGLYKIRNSVDVKLHPIAQRDMVIIQLPKDFPPFPMRLKFSTPSRDVRVCLVGINFQQNHTTCIISESSVTAPKGNGDFWKHWISTVDGQCGLPLVDVKNKHIVGIHSLASTSGNTNFFVAMPENFNEYISNLVQTNKWEKGWHYNPNLISWCGLNLVDSAPKGLFKTSKLVEDLDMSVEEQCKVTETWLTEHIQDNLQVVAKCPGQLVTKHVVKGPCPHFQLYLSTHDEAKLYFSPLLGKYDKSRLNRAAFIKDLSKYAKPIYIGEINYEIFDKAVDRVISILRSVGMLQCTYVTDEEEIFNSLNMNAAVGALYTGKKKDYFKDFSNDDKAEIIMRSCERIYNGQLGVWNGSLKAEIRPIEKTILNKTRTFTAAPLETLLGGKVCVDDFNNQFYSHHLEGPWTVGITKFYGGWNRLLEKLPEGWIYCDADGSQFDSSLTPYLINAVLHIRLHFMEEWELGAQMLRNLYTEIVYTPIATPDGSVIKKFKGNNSGQPSTVVDNTLMVIIAFNYAMLSSGIPEDKIDDCCRMFANGDDLLLAVHPDYEYILDGFQNHFGNLGLNFEFTSRTKDKSELWFMSTQGVKCEGIYIPKLERERIVAILEWDRSNLPEHRLEAICAAMVEAWGYPDLVHEIRKFYAWLLEMQPFANLAKEGMAPYIAETALRNLYLGTGIKEEEIEKYFRQFVKDLPGYVEDYNEEVIHQSGQVDAGRQGGSGAQGGTPPAGSGGTGSGTQGNGGQTGSQGSSGQQGSGGGTGQGAAGNNGGGQTGGRLHFLSSNDKCQ

Features

Showing features for compositional bias, non-terminal residue.

TypeIDPosition(s)Description
Compositional bias2773-2833Polar residues
Non-terminal residue2833

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK481075
EMBL· GenBank· DDBJ
QEE60086.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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