A0A5B9FYZ1 · A0A5B9FYZ1_9POTV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2833 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 579 | For helper component proteinase activity | ||||
Sequence: C | ||||||
Active site | 656 | For helper component proteinase activity | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasmic vesicle | |
Cellular Component | host cell nucleus | |
Cellular Component | membrane | |
Cellular Component | viral capsid | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | structural molecule activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Stelpaviricetes > Patatavirales > Potyviridae > Potyvirus
Accessions
- Primary accessionA0A5B9FYZ1
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 955-977 | Helical | ||||
Sequence: LMHIFIVLSLLTTVANTIIVTMN |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts with host eIF4E protein (via cap-binding region); this interaction mediates the translation of the VPg-viral RNA conjugates (By similarity).
Part of a complex that comprises VPg, RNA, host EIF4E and EIF4G; this interaction mediates the translation of the VPg-viral RNA conjugates
Part of a complex that comprises VPg, RNA, host EIF4E and EIF4G; this interaction mediates the translation of the VPg-viral RNA conjugates
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 99-233 | Peptidase S30 | ||||
Sequence: KPVNTSINKLIRDVLDISKGSSLKLELIGKRQKCRTQLAIKKYNNKDYLHCRTRHEDNMFKRRDVAIGIEWIPTIEAIARCYSTVNKQEMQSLYKGSSGLTFMQNDELFIVRGRMNGELVNSLEENKNVLDIDHY | ||||||
Domain | 571-697 | Peptidase C6 | ||||
Sequence: MYIAKDGYCYINIFLAAMINVNEDSAKDYTKFLRDELVERLGKWXXXXXXLKDVATACYALSVMFPEIKNAELPPILVDHESKSMHVIDSYGSLSVGFHILKASTVGQLIKFQYESMDSEMREYIVG | ||||||
Domain | 1186-1338 | Helicase ATP-binding | ||||
Sequence: LAHSNLEKEFLLRGAVGSGKSTGLPYHLSMRGKVLLIEPTRPLAENVCRQLQGPPFNVSPTLQMRGLSSFGCTPITIMTSGFALHMYANNPDKISDYDFIIFDECHIMEAPAMAFYCLLKEYEYRGKIIKVSATPPGRECEFSTQHPVDIHVC | ||||||
Domain | 1357-1516 | Helicase C-terminal | ||||
Sequence: DATKYGNNILVYVASYNDVDSLAHALTELHYSVIKVDGRTMKQNTTGIVTNGTSQKKCFVVATNIIENGVTLDVDVVVDFGLKVTAELDVDNRAILYKRVSISYGERIQRLGRVGRNKPGTVVRIGKTMKGLQEIPAMIATEAAFMCFAYGLKVITHNVS | ||||||
Domain | 1992-2210 | Peptidase C4 | ||||
Sequence: SKSMMAGLGDYTPISQQLCLVQNDSEGVKRNVYAIGYGSYLISPAHLFKYNNGEITIKSSRGLYKIRNSVDVKLHPIAQRDMVIIQLPKDFPPFPMRLKFSTPSRDVRVCLVGINFQQNHTTCIISESSVTAPKGNGDFWKHWISTVDGQCGLPLVDVKNKHIVGIHSLASTSGNTNFFVAMPENFNEYISNLVQTNKWEKGWHYNPNLISWCGLNLVD | ||||||
Domain | 2476-2600 | RdRp catalytic | ||||
Sequence: WIYCDADGSQFDSSLTPYLINAVLHIRLHFMEEWELGAQMLRNLYTEIVYTPIATPDGSVIKKFKGNNSGQPSTVVDNTLMVIIAFNYAMLSSGIPEDKIDDCCRMFANGDDLLLAVHPDYEYIL | ||||||
Region | 2754-2833 | Disordered | ||||
Sequence: QSGQVDAGRQGGSGAQGGTPPAGSGGTGSGTQGNGGQTGSQGSSGQQGSGGGTGQGAAGNNGGGQTGGRLHFLSSNDKCQ | ||||||
Compositional bias | 2773-2833 | Polar residues | ||||
Sequence: PPAGSGGTGSGTQGNGGQTGSQGSSGQQGSGGGTGQGAAGNNGGGQTGGRLHFLSSNDKCQ |
Sequence similarities
Belongs to the potyviridae genome polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length2,833
- Mass (Da)319,922
- Last updated2019-11-13 v1
- Checksum04FEA75D702CEC39
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2773-2833 | Polar residues | ||||
Sequence: PPAGSGGTGSGTQGNGGQTGSQGSSGQQGSGGGTGQGAAGNNGGGQTGGRLHFLSSNDKCQ | ||||||
Non-terminal residue | 2833 | |||||
Sequence: Q |