A0A5B9EPR6 · A0A5B9EPR6_9RHOB
- ProteinGlycerol kinase
- GeneglpK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Catalytic activity
- ATP + glycerol = ADP + H+ + sn-glycerol 3-phosphate
Activity regulation
Inhibited by fructose 1,6-bisphosphate (FBP).
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 11 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 11 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 12 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 13 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 15 | ADP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 81 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 81 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 82 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 82 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 133 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 133 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 242 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 242 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 243 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 264 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 264 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 307 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 307 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 311 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 410 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 410 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | glycerol kinase activity | |
Biological Process | glycerol catabolic process | |
Biological Process | glycerol-3-phosphate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Octadecabacter
Accessions
- Primary accessionA0A5B9EPR6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-249 | Carbohydrate kinase FGGY N-terminal | ||||
Sequence: ILAIDQGTTSSRAIIFDADMAIAATAQKEFTQHFPHSGWVEHDIDEIWSTVVTTCREAMEKAGLSAGDIAAIGITNQRETTLVWDRKTGEPVHNAIVWQDRRTADFCAQLRAEGFEAEITQRTGLLADPYFSATKVHYILNTVAGAQARAEAGELLFGTVDCYLIWKLTGGRVHATDATNAARTMLYNIRDGAWDDTICQRLDIPRAMLPEVRDCAADFGETRADLFGAPIPILGVAGDQQAATIG | ||||||
Domain | 260-448 | Carbohydrate kinase FGGY C-terminal | ||||
Sequence: STYGTGCFALLNTGDTLVESRNRMLGTIAYQLDGKPTYALEGSIFIAGAVVQWLRDGLGVIGAADETQALAEKADPSQELYLVPAFTGLGAPHWDAKARGAIYGLTRNSGPAEFARAALESVGFQTRDLLEAMQADWAQAEEASVLRVDGGMSASDWSMQFLSDIIGAPVDRPQVLETTALGAAWLAGM |
Sequence similarities
Belongs to the FGGY kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)53,599
- Last updated2019-11-13 v1
- Checksum3F0EE63D4FC8286D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP042819 EMBL· GenBank· DDBJ | QEE35656.1 EMBL· GenBank· DDBJ | Genomic DNA |