A0A5B9BJ80 · A0A5B9BJ80_9MUSC
- ProteinCytochrome c oxidase subunit 1
- GeneCO1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionA0A5B9BJ80
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 7-28 | Helical | |||
Transmembrane | 48-74 | Helical | |||
Transmembrane | 95-117 | Helical | |||
Transmembrane | 137-162 | Helical | |||
Transmembrane | 174-201 | Helical | |||
Transmembrane | 221-242 | Helical | |||
Transmembrane | 263-282 | Helical | |||
Transmembrane | 294-316 | Helical | |||
Transmembrane | 328-350 | Helical | |||
Transmembrane | 370-391 | Helical | |||
Transmembrane | 403-421 | Helical | |||
Transmembrane | 441-464 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length495
- Mass (Da)54,457
- Last updated2019-11-13 v1
- MD5 Checksum98DE56C68134F5F03BAF10A309397EEA
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 495 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MN262235 EMBL· GenBank· DDBJ | QED88404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262236 EMBL· GenBank· DDBJ | QED88405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262237 EMBL· GenBank· DDBJ | QED88406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262238 EMBL· GenBank· DDBJ | QED88407.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262239 EMBL· GenBank· DDBJ | QED88408.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262240 EMBL· GenBank· DDBJ | QED88409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262241 EMBL· GenBank· DDBJ | QED88410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262242 EMBL· GenBank· DDBJ | QED88411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262243 EMBL· GenBank· DDBJ | QED88412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262244 EMBL· GenBank· DDBJ | QED88413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262245 EMBL· GenBank· DDBJ | QED88414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262246 EMBL· GenBank· DDBJ | QED88415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262247 EMBL· GenBank· DDBJ | QED88416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262248 EMBL· GenBank· DDBJ | QED88417.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262249 EMBL· GenBank· DDBJ | QED88418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262250 EMBL· GenBank· DDBJ | QED88419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262251 EMBL· GenBank· DDBJ | QED88420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262252 EMBL· GenBank· DDBJ | QED88421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262253 EMBL· GenBank· DDBJ | QED88422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN262254 EMBL· GenBank· DDBJ | QED88423.1 EMBL· GenBank· DDBJ | Genomic DNA |