A0A5B8YW79 · A0A5B8YW79_9CALI

  • Protein
    Genome polyprotein
  • Gene
    ORF1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site1039For 3CLpro activity
Active site1063For 3CLpro activity
Active site1148For 3CLpro activity

GO annotations

AspectTerm
Cellular Componenthost cell membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Gene names

    • Name
      ORF1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 181_GII.Pe_GII.4_Araguaina
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Norovirus > Norwalk virus

Accessions

  • Primary accession
    A0A5B8YW79

Subcellular Location

PTM/Processing

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.

Keywords

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-31Polar residues
Region1-79Disordered
Compositional bias42-76Pro residues
Region94-121Disordered
Compositional bias97-113Polar residues
Domain465-632SF3 helicase
Region871-892Disordered
Domain1010-1190Peptidase C37
Domain1426-1547RdRp catalytic

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,700
  • Mass (Da)
    188,728
  • Last updated
    2019-11-13 v1
  • Checksum
    BC1D9C21236F710D
MKMASNDASAAAVANSNNDIAKSSSDGVFSNMAVTFKRPLGARPKQPPPKEIPPRPPRPPTPELGKKIPPPPPNGEDELVVSYSAKDGVSGLPELTTVRQPEETNTAFSVPPLNQRESRDAKEPLTGTIIEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELTPLSLFWRPVYTPQYLISPYTLRSLHCDSFPYTAFYNSCYAFCCWVLDLNDSWLSRRMIQRTTGFFRPYQDWNRKPLPTMDDSKLKKVANIFLCTLSSLFTRPIKDIIGKLKPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGPEDLVVELVPIVMGGIGLVLGFTKEKIGKMLSSAASTLRACKALGAYGLEILKLVMKRLFPKKEEANELAMVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINSLLARIAAARSLVHRAKEELSSCWRAVVVMISGRPGIGKTHLARHLAKKIAASLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMRHPIQGALRLQELAYTSPFTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQPDMWKNAFSPDFSHIKLSLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDVDTMKGPALTTFNLENSPILAFRQLAAENKYGLMDTMKVGKQLKDVKTMSDLKQALKNIAIKKCQIVYNGSTYTLEADGRGSVKVDKVQSATVHFVNHLAGALHHLRCARIRYYVKCVQEALYSMIQIAGAAFVTTRIAMRVNIQNLWSKPQVEDTEEMTSKDGCLKPKDDEEFVVSSDDIKTEGKKGKNKSDRTPHHWAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDRYYEEVVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASLGLVTGSEIRKRNPEDFKPKGKPWADDDRRVDYNEKLNFEAPPSIWSRIVNFGSGWGFWVSPSLNTKLTHIIPHGAKEFFGVPIKQIQIHKSGELCRLRFPNPIGTDVAGMILEEGALGGTVGALPICPPTGAPLNLSVRMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKTKFWRSSTTPLPPGTYVPAYLGGKDPRVKGGPSLQHVMRDQLKPFTEPRGKPPRPTVLGDARKTIISVRGQTIVAPRKWSVAQACASLDKTSSCGQPQHMRKNDCWNGGSVTGKLADQASKANLMFEEGKNMTPVYTGALKDELVKTDKVYAKIKKRLLWGSDLATMIRCARAFGGLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRDVLAAALEIMVKFSPEPHLGQVVADDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLLTLCALSDVRDRSRDFIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHADPFETMIPHSPRPIQLMSLLGEAALHGPAFYSQLCKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSGVNEDGVE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-31Polar residues
Compositional bias42-76Pro residues
Compositional bias97-113Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN308019
EMBL· GenBank· DDBJ
QED42445.1
EMBL· GenBank· DDBJ
Genomic RNA

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