A0A5B8YW25 · A0A5B8YW25_9CALI

  • Protein
    Genome polyprotein
  • Gene
    ORF1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.

Catalytic activity

Features

Showing features for active site.

116632004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Active site1002For 3CLpro activity
Active site1026For 3CLpro activity
Active site1111For 3CLpro activity

GO annotations

AspectTerm
Cellular Componenthost cell membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Gene names

    • Name
      ORF1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 074_GII.Pe_GII.4_Araguaina
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Norovirus > Norwalk virus

Accessions

  • Primary accession
    A0A5B8YW25

Subcellular Location

PTM/Processing

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-42Disordered
Compositional bias9-39Pro residues
Compositional bias62-76Polar residues
Region62-84Disordered
Domain428-595SF3 helicase
Region834-854Disordered
Domain973-1153Peptidase C37
Domain1389-1510RdRp catalytic

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,663
  • Mass (Da)
    185,465
  • Last updated
    2019-11-13 v1
  • Checksum
    4006DDF9C3989FD3
RALGARPKQPPPKEIPPRPPRPPTPELVKKIPPPPPNGEDELVVSYSAKDGVSGLPELTTVRQPEETNTAFSVPPLNQRESRDAKEPLTGTIIEMWDGEIYHYGLYVERGLILGVHKPPAAISLAKVELAPLSLFWRPVYTPQYLISPDTLRRLHCESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQRTTGFFRPYQDWNRKPLPTMDDSKLKKVANIFLCTLSSLFTRPIKDIIGKLKPLNILNILATCDWTFAGIVESLILLAELFGVFRTPPDVSAMIAPLLGDYELQGPEDLAVELVPIVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEANELAMVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINSLLARIAAARSLVHRAKEELSSRPRAVVVMISGRPGIGKTHLARELAKKIAASLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQHDMWKNAFSPDFSHIKLSLATQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEYELQGPALTTFNFDRNQILAFRQLAAENKYGLMDTMKVGKQLKDVKTMSDLKQALKNIAIKKCQIVYDGGTYTLEADGKGSVKVDKVQSATVQTNNELAGALHHLRCARIRYYVKCVQEALYSIIQIAGAAFVTTRIAKRMNIQNLWSKPQVEDTEEMASKDGCLKPKDDEEFVVSSDDIKTEGKKGKNKSHRTPHHWAFSSKGLSDEEYDEYKRIREERNGKYSIEEYLQDRDRYSSMEVAIARATEEDFCEEEEAKIRQRIFRPTRKQRKEERASFGLVTGSEIRKKNPEDFKPKGKLWADDDRSVDYNEKLNFEAPPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPHGAKEFFGVPIKQIQIHKLGEFCRLRFPKPIRTGVTGMILEEGAPEGTVATLLIKRPTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAAARGGNTVICATQGSEGEATLEGGDSKGTYCGAPILGPGSAPKLSTKTKFWRSSTTPLPPGTYEPAYLGGKDPRVKGGPSLQQVMTDHLKPFTEPRGKPPRPNVLEAAKKTIINVLEQTIDPPQKWSFAQACASLDKTTSSGHPHPMRKNDCWNGESFTGKLADQASKANLMFEEGKNMTPIYTGALKDELVKTDKVYGKVKKRLLWGSDLATMIRCARAFGGLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYRYHYDADYSRWDSTQQRDVLAAALEIMVKFSPEPHLAQVVAEDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLLTLCALSEVTDLSPDIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLDGLTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHADPFETMIPHSLRPIQLMSLLGEAALHGPAFYSKLSKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLNMWEGDRNLAPSFVNEDGVE

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias9-39Pro residues
Compositional bias62-76Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN308005
EMBL· GenBank· DDBJ
QED42403.1
EMBL· GenBank· DDBJ
Genomic RNA

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