A0A5B7WQ57 · A0A5B7WQ57_9MICC

Function

function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.

Features

Showing features for site, binding site.

TypeIDPosition(s)Description
Site21Transition state stabilizer
Site28Transition state stabilizer
Site162Positions MEP for the nucleophilic attack
Site222Positions MEP for the nucleophilic attack
Binding site258a divalent metal cation (UniProtKB | ChEBI)
Binding site258-2604-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site260a divalent metal cation (UniProtKB | ChEBI)
Site286Transition state stabilizer
Binding site286-2874-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site294a divalent metal cation (UniProtKB | ChEBI)
Binding site308-3104-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site381-3844-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Site382Transition state stabilizer

GO annotations

AspectTerm
Molecular Function2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Molecular Function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Molecular Functionmetal ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
  • EC number
  • Short names
    MECDP-synthase
    ; MECPP-synthase
    ; MECPS
  • Recommended name
    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
  • EC number
  • Alternative names
    • 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
    • MEP cytidylyltransferase
      (MCT
      )

Gene names

    • Name
      ispDF
    • Synonyms
      ispD
      , ispF
    • ORF names
      GcLGCM259_0422

Organism names

Accessions

  • Primary accession
    A0A5B7WQ57

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain252-4032-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Sequence similarities

Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Belongs to the IspF family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    407
  • Mass (Da)
    42,751
  • Last updated
    2019-11-13 v1
  • Checksum
    EFCCB17C0693E0D0
MNEHPNVDAALILVAAGSGTRLGAGIPKALVTIEGRSLLQHCLDRATQVAELAQIVVVVPPSDELLAEQARPYGPRVSCVPGGATRAESVGAGLEAVDQRLTRILVHDVARALTPPDTFERVLQTLEDPQRPAVIPALPVIDTISVVEQTSGSDTVRDTPARASLRAVQTPQGFHAPVLRAAHAALREASDARREAVTDDASLVRAQGHSVTVIAGDQRALKITHPQDIHAARTILRDDTEEDAMDQPLIPRIGNAIDVHAVSKDPQRPMWLAGLLFADDVGLDGHSDGDAVAHAACDALFSAAGIGDLGTHFGVDRPEMAGASGTTLLAEAARIVRAAGYQIGNVSVQFVGRRPRFAARREEANQVLSDAAQASVTVTATTSDGLGYEGEGAGITAYATALVYRRD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP034412
EMBL· GenBank· DDBJ
QCY46198.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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