A0A5B6UHE8 · A0A5B6UHE8_9ROSI

  • Protein
    Lactoylglutathione lyase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site31Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site97Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site125Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site167Proton donor/acceptor
Binding site167Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • ORF names
      EPI10_003400

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • cv. PA1801
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Malvoideae > Gossypium

Accessions

  • Primary accession
    A0A5B6UHE8

Proteomes

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-22Disordered
Domain28-171VOC

Sequence similarities

Belongs to the glyoxalase I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    182
  • Mass (Da)
    20,741
  • Last updated
    2019-11-13 v1
  • MD5 Checksum
    A4C5A9887CBAF30385935406EBD17AA9
MASLDSKESPANNPGLHFPPDEVTKGYIMQQTMFRIKDPKRTLEFYSRVLGMTLLNKVDVPYMKMTLYMMGYEDVSSAPSDPVEKTIWTFGRPATMELTHFWGTENDPEFKGYHDGNSEPIGFGHIGITVDDMYKACERFESLGVEFVKKPSDGFAFIKDPDGYWIEIFDLKGIRQIVNSLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SMMG02000011
EMBL· GenBank· DDBJ
KAA3456618.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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