A0A5B3GTC4 · A0A5B3GTC4_9BACT

  • Protein
    Fluoride-specific ion channel FluC
  • Gene
    fluC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site72Na+ (UniProtKB | ChEBI); structural
Binding site75Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • ORF names
      F2Y10_12215

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BIOML-A266
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Rikenellaceae > Alistipes

Accessions

  • Primary accession
    A0A5B3GTC4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-22Helical
Transmembrane34-56Helical
Transmembrane62-80Helical
Transmembrane92-116Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    122
  • Mass (Da)
    12,453
  • Last updated
    2020-02-26 v1
  • Checksum
    18F02D21808CA6E7
MIRELLAVGCGGAAGSIVRYLLSGGIMAGQTLLGFPAGTFTVNAAGSLLIGILLEATSSETLGWLLIVGFCGGFTTFSTFSADAVRLLRAECYTAAAYVGLSVAVCIVFAAAGMWIGTTFRN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VVXH01000013
EMBL· GenBank· DDBJ
KAA2376853.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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