A0A5B0WPY1 · A0A5B0WPY1_9GAMM

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site255-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site59-615-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site83-855-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site88-89(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site91Proton donor
Binding site1165-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site130(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribE
    • Synonyms
      ribH
    • ORF names
      F0M18_16710

Organism names

  • Taxonomic identifier
  • Strain
    • NY5
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Cellvibrionales > Halieaceae > Pseudohalioglobus

Accessions

  • Primary accession
    A0A5B0WPY1

Proteomes

Subcellular Location

Interaction

Subunit

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    157
  • Mass (Da)
    16,604
  • Last updated
    2019-11-13 v1
  • Checksum
    4488D9842748386D
MSDIKTVEGDFTSGKGSYTIVVGRWNSFVVEHLLEGAVDCLRRHGVSRSQITIVRAPGAFEIPLVCKQIAAKGEVDAIIALGAVIRGGTPHFEYVAGECTKGLAMVSMEYGVPVSFGVLTVDTIEQAVERSGTKAGNKGEEAAMSALEMVSLMQKLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VTUX01000009
EMBL· GenBank· DDBJ
KAA1188846.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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