A0A5A7QD13 · A0A5A7QD13_STRAF
- ProteinSerine hydroxymethyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids655 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Interconversion of serine and glycine.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | cobalt ion binding | |
Molecular Function | glycine hydroxymethyltransferase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | serine binding | |
Molecular Function | zinc ion binding | |
Biological Process | folic acid metabolic process | |
Biological Process | glycine biosynthetic process from serine | |
Biological Process | L-serine catabolic process | |
Biological Process | methylation | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine hydroxymethyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Lamiales > Orobanchaceae > Buchnereae > Striga
Accessions
- Primary accessionA0A5A7QD13
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-33 | Disordered | ||||
Sequence: MDLTRPPGNSGLSLGIPSHVSATPSNNTTERHS | ||||||
Compositional bias | 14-30 | Polar residues | ||||
Sequence: LGIPSHVSATPSNNTTE | ||||||
Region | 71-90 | Disordered | ||||
Sequence: GHSRAENNSNENNNIEDDEN | ||||||
Region | 106-134 | Disordered | ||||
Sequence: RKRDSDLGGSSTSMCSFNKESRNPSNEME | ||||||
Compositional bias | 113-128 | Polar residues | ||||
Sequence: GGSSTSMCSFNKESRN | ||||||
Domain | 148-534 | Serine hydroxymethyltransferase-like | ||||
Sequence: LQNADPEIFMIMDKEKQRQFKGIELIASENFVCKAVMEALGSHLTNKYSEGMPGARYYGGNQYIDEIENLCRERALAAFGLDSASWGVNVQPYSCTSANFAVYTGLLLPGDRIMGLDTPSGGNTSHGCYLPNGRKVSGASIFFENLPYKVNPQTGYVDCDKLEERALDFRPKILICGGSSYPREWDYPRFRQIADKCGAVLLCDMAQISGLIAAKECASPFEYCDIVTSTTHKSLRGPRGGIIFYRKGPKPKKRGILLTQGDCSDRYDFEEKINFAVFPALQGGPHNNHIAALAIALKQVATPEFKAYMQQVKKNAQVLASALLRRNCKLVTGGTDSHMLLWDLRNFGLTGKNFEKVCELCHITLNKVTIFDDNGNITPGGVRIGMN |
Sequence similarities
Belongs to the SHMT family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length655
- Mass (Da)72,819
- Last updated2019-11-13 v1
- ChecksumB3AADFA6F345E92A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 14-30 | Polar residues | ||||
Sequence: LGIPSHVSATPSNNTTE | ||||||
Compositional bias | 113-128 | Polar residues | ||||
Sequence: GGSSTSMCSFNKESRN |
Keywords
- Technical term