A0A5A7PQG9 · A0A5A7PQG9_STRAF

Function

function

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.
    EC:6.2.1.45 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

111481002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Active site724Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionubiquitin activating enzyme activity
Biological ProcessDNA damage response
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E1 ubiquitin-activating enzyme
  • EC number

Gene names

    • ORF names
      STAS_10965

Organism names

  • Taxonomic identifier
  • Strain
    • cv. UVA1
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Lamiales > Orobanchaceae > Buchnereae > Striga

Accessions

  • Primary accession
    A0A5A7PQG9

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias30-49Polar residues
Region30-51Disordered
Domain1021-1143Ubiquitin-activating enzyme E1 C-terminal

Sequence similarities

Belongs to the ubiquitin-activating E1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,148
  • Mass (Da)
    128,641
  • Last updated
    2019-11-13 v1
  • Checksum
    8BEFD92A453EC675
MLPIKRQGEGEAVNDPDSEILLKKQRDCFSSTNSTDELNSNSKGTGSLEEPTITEMAFDDGKPNDIDEDLHSRQLAVYGRETMRRLFASNVLVSGMQGLGAEIGGIVERADYIPFGLVLLAFVLLPVEPLIQFLLDFGLQLLLAKNLILAGVKSVTLHDEGTVELWDLSSNFVFSEKDLGKNRALASIQKLQELNNAVAISTLTTKLSVEQLSDFQAVVFTDIDLKRAIEFNEFCHNHQPPIAFIKTEVRGLFGSVFCDFGPEFTVFDVDGEEPHTGIIASISNDNPSLVGCVDDERLEFQDGDLVVFSEIRGMTELNDGKTRKIKNARPYSFTLEEDTTNFGRYERGGIVTQVKQPKVLNFKPLKEAIKDPGDFLLSDFSKFDRPPLLHLAFQALDNFVSEMGRFPVAGSEEDAQRLISVTSDMNESLGDGKLDINPKLLRHFAFGARAVLNPMAAMFGGIVGQEVVKACSGKFHPLFQLGTIFAGKRDQIARIVSFLDAHGTYLICMWPHLWLKFFYFDSIESLPTEISDPSDFRPLNSRYDAQISVFGSKLQKKLEDAKVFVVGSGALGCEFLKNLALMGVSCGKQGKLTITDDDVIEKSNLSRQFLFRDWNIGQPKSTVAASAALSINPHFHIEALQNRVGPETETVFDDAFWENLSVVINALDNVNARLYVDQRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSNPVEYASAMRNAGDAQARDNLERVIECLDRERCESFQDCITWARLKFEDYFANRVKQLTFTFPEDAATSTGAPFWSAPKRFPRPLQFSNTDPSHLHFVMAGSILRAETFGIPVPDWAKSPMKLAEAVDNVIVPDFQPKKDVKIVTDEKATSLATSSMDDAAVIDELIAKLEKCRETLAAKFMMKPIQFEKDDDTNYHMDLISALANMRARNYSIPEVDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKAIDNNHKVEDYRNTFANLALPLFSMAEPVPPKLFKHRDMSWTVWDRWIVRENPTLRELLRWLADKGLNAYSISFGSCLLYNSMFPRHRERMDRKVAELARDVAKVELPRGRGHLDVVVACEDEDDNDIDIPQVSVYFR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias30-49Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BKCP01004949
EMBL· GenBank· DDBJ
GER34712.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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