A0A5A4MI30 · A0A5A4MI30_9EUCA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Brachyura > Eubrachyura > Grapsoidea > Gecarcinidae > Cardisoma

Accessions

  • Primary accession
    A0A5A4MI30

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-48Helical
Transmembrane113-136Helical
Transmembrane148-175Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-193Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    193
  • Mass (Da)
    20,597
  • Last updated
    2019-11-13 v1
  • Checksum
    3A330E59F0116490
IIRAELSQPGSLIGNDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLSLLLTSSMVESGVGTGWTVYPPLAAAIAHAGASVDLGIFSLHLAGVSSILGAVNFMTTVINMRSYGMTMDQMPLFVWAVFITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue193

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF583047
EMBL· GenBank· DDBJ
AXU22006.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583048
EMBL· GenBank· DDBJ
AXU22007.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583049
EMBL· GenBank· DDBJ
AXU22008.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583050
EMBL· GenBank· DDBJ
AXU22009.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583051
EMBL· GenBank· DDBJ
AXU22010.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583052
EMBL· GenBank· DDBJ
AXU22011.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583053
EMBL· GenBank· DDBJ
AXU22012.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583054
EMBL· GenBank· DDBJ
AXU22013.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583055
EMBL· GenBank· DDBJ
AXU22014.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583056
EMBL· GenBank· DDBJ
AXU22015.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583057
EMBL· GenBank· DDBJ
AXU22016.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583058
EMBL· GenBank· DDBJ
AXU22017.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583059
EMBL· GenBank· DDBJ
AXU22018.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583060
EMBL· GenBank· DDBJ
AXU22019.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583061
EMBL· GenBank· DDBJ
AXU22020.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583062
EMBL· GenBank· DDBJ
AXU22021.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583063
EMBL· GenBank· DDBJ
AXU22022.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583064
EMBL· GenBank· DDBJ
AXU22023.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583065
EMBL· GenBank· DDBJ
AXU22024.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583066
EMBL· GenBank· DDBJ
AXU22025.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583067
EMBL· GenBank· DDBJ
AXU22026.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583069
EMBL· GenBank· DDBJ
AXU22028.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583070
EMBL· GenBank· DDBJ
AXU22029.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583072
EMBL· GenBank· DDBJ
AXU22031.1
EMBL· GenBank· DDBJ
Genomic DNA
MF583073
EMBL· GenBank· DDBJ
AXU22032.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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