A0A590UK53 · A0A590UK53_HUMAN
- ProteinLDL receptor related protein 8
- GeneLRP8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids673 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Biological Process | endocytosis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A590UK53
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 533-558 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 17↔35 | ||||
Disulfide bond | 29↔44 | ||||
Disulfide bond | 49↔61 | ||||
Disulfide bond | 56↔74 | ||||
Disulfide bond | 68↔83 | ||||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 109-124 | EGF-like | |||
Repeat | 172-218 | LDL-receptor class B | |||
Repeat | 219-261 | LDL-receptor class B | |||
Repeat | 262-305 | LDL-receptor class B | |||
Repeat | 306-350 | LDL-receptor class B | |||
Region | 464-525 | Disordered | |||
Sequence similarities
Belongs to the LDLR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length673
- Mass (Da)74,590
- Last updated2019-11-13 v1
- MD5 Checksum94D4B4801B429E05DC4D5B9E4A058F06
Computationally mapped potential isoform sequences
There are 22 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q14114 | LRP8_HUMAN | LRP8 | 963 | ||
H0YEA5 | H0YEA5_HUMAN | LRP8 | 135 | ||
H0YEV6 | H0YEV6_HUMAN | LRP8 | 157 | ||
H0YCA4 | H0YCA4_HUMAN | LRP8 | 143 | ||
A0A590UKB5 | A0A590UKB5_HUMAN | LRP8 | 234 | ||
A0A590UKB1 | A0A590UKB1_HUMAN | LRP8 | 808 | ||
A0A590UJT0 | A0A590UJT0_HUMAN | LRP8 | 708 | ||
A0A590UK45 | A0A590UK45_HUMAN | LRP8 | 888 | ||
A0A590UJQ4 | A0A590UJQ4_HUMAN | LRP8 | 86 | ||
A0A590UK97 | A0A590UK97_HUMAN | LRP8 | 790 | ||
A0A590UJV3 | A0A590UJV3_HUMAN | LRP8 | 200 | ||
A0A590UK84 | A0A590UK84_HUMAN | LRP8 | 766 | ||
A0A590UJJ8 | A0A590UJJ8_HUMAN | LRP8 | 732 | ||
A0A590UJJ9 | A0A590UJJ9_HUMAN | LRP8 | 124 | ||
A0A590UJF9 | A0A590UJF9_HUMAN | LRP8 | 926 | ||
A0A590UJH5 | A0A590UJH5_HUMAN | LRP8 | 537 | ||
A0A590UJ98 | A0A590UJ98_HUMAN | LRP8 | 834 | ||
A0A590UJ30 | A0A590UJ30_HUMAN | LRP8 | 74 | ||
A0A590UJ39 | A0A590UJ39_HUMAN | LRP8 | 175 | ||
A0A590UJ57 | A0A590UJ57_HUMAN | LRP8 | 888 | ||
E9PP15 | E9PP15_HUMAN | LRP8 | 841 | ||
E9PKG2 | E9PKG2_HUMAN | LRP8 | 594 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL355483 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL606760 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |