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A0A590UK53 · A0A590UK53_HUMAN

  • Protein
    LDL receptor related protein 8
  • Gene
    LRP8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Biological Processendocytosis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • LDL receptor related protein 8

Gene names

    • Name
      LRP8

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A590UK53

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane533-558Helical

Keywords

  • Cellular component

Disease & Variants

Genetic variation databases

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond17↔35
Disulfide bond29↔44
Disulfide bond49↔61
Disulfide bond56↔74
Disulfide bond68↔83

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, repeat, region.

Type
IDPosition(s)Description
Domain109-124EGF-like
Repeat172-218LDL-receptor class B
Repeat219-261LDL-receptor class B
Repeat262-305LDL-receptor class B
Repeat306-350LDL-receptor class B
Region464-525Disordered

Sequence similarities

Belongs to the LDLR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    673
  • Mass (Da)
    74,590
  • Last updated
    2019-11-13 v1
  • MD5 Checksum
    94D4B4801B429E05DC4D5B9E4A058F06
GATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP

Computationally mapped potential isoform sequences

There are 22 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q14114LRP8_HUMANLRP8963
H0YEA5H0YEA5_HUMANLRP8135
H0YEV6H0YEV6_HUMANLRP8157
H0YCA4H0YCA4_HUMANLRP8143
A0A590UKB5A0A590UKB5_HUMANLRP8234
A0A590UKB1A0A590UKB1_HUMANLRP8808
A0A590UJT0A0A590UJT0_HUMANLRP8708
A0A590UK45A0A590UK45_HUMANLRP8888
A0A590UJQ4A0A590UJQ4_HUMANLRP886
A0A590UK97A0A590UK97_HUMANLRP8790
A0A590UJV3A0A590UJV3_HUMANLRP8200
A0A590UK84A0A590UK84_HUMANLRP8766
A0A590UJJ8A0A590UJJ8_HUMANLRP8732
A0A590UJJ9A0A590UJJ9_HUMANLRP8124
A0A590UJF9A0A590UJF9_HUMANLRP8926
A0A590UJH5A0A590UJH5_HUMANLRP8537
A0A590UJ98A0A590UJ98_HUMANLRP8834
A0A590UJ30A0A590UJ30_HUMANLRP874
A0A590UJ39A0A590UJ39_HUMANLRP8175
A0A590UJ57A0A590UJ57_HUMANLRP8888
E9PP15E9PP15_HUMANLRP8841
E9PKG2E9PKG2_HUMANLRP8594

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL355483
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL606760
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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