A0A571BET0 · A0A571BET0_MOUSE
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha
- GeneCacna1a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2457 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell projection | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | high voltage-gated calcium channel activity | |
Molecular Function | metal ion binding | |
Molecular Function | syntaxin binding | |
Biological Process | cellular response to amyloid-beta | |
Biological Process | modulation of chemical synaptic transmission | |
Biological Process | positive regulation of cytosolic calcium ion concentration |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A571BET0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 193-210 | Helical | ||||
Sequence: YMILATIIANCIVLALEQ | ||||||
Transmembrane | 230-250 | Helical | ||||
Sequence: YFIGIFCFEAGIKIVALGFAF | ||||||
Transmembrane | 313-336 | Helical | ||||
Sequence: AMIPLLQIGLLLFFAILIFAIIGL | ||||||
Transmembrane | 428-450 | Helical | ||||
Sequence: WLYFIPLIIIGSFFMLNLVLGVL | ||||||
Transmembrane | 579-598 | Helical | ||||
Sequence: AFYWTVLSLVALNTLCVAIV | ||||||
Transmembrane | 610-630 | Helical | ||||
Sequence: LYYAEFIFLGLFMSEMFIKMY | ||||||
Transmembrane | 705-727 | Helical | ||||
Sequence: IISLLFLLFLFIVVFALLGMQLF | ||||||
Transmembrane | 781-805 | Helical | ||||
Sequence: FSIYFIVLTLFGNYTLLNVFLAIAV | ||||||
Transmembrane | 1283-1302 | Helical | ||||
Sequence: LRYFEMCILMVIAMSSIALA | ||||||
Transmembrane | 1322-1343 | Helical | ||||
Sequence: YVFTGVFTFEMVIKMIDLGLVL | ||||||
Transmembrane | 1355-1372 | Helical | ||||
Sequence: ILDFIVVSGALVAFAFTG | ||||||
Transmembrane | 1417-1439 | Helical | ||||
Sequence: VFNILIVYMLFMFIFAVVAVQLF | ||||||
Transmembrane | 1529-1554 | Helical | ||||
Sequence: IFYVVYFVVFPFFFVNIFVALIIITF | ||||||
Transmembrane | 1610-1628 | Helical | ||||
Sequence: YTIMAMIALNTIVLMMKFY | ||||||
Transmembrane | 1640-1663 | Helical | ||||
Sequence: VFNIVFTSLFSLECVLKVMAFGIL | ||||||
Transmembrane | 1731-1749 | Helical | ||||
Sequence: ALPYVCLLIAMLFFIYAII | ||||||
Transmembrane | 1827-1851 | Helical | ||||
Sequence: AYFYFVSFIFLCSFLMLNLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 374 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Expression
Gene expression databases
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 801-837 | |||||
Sequence: LAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV | ||||||
Region | 851-870 | Disordered | ||||
Sequence: AVKEQQKNQKPTKSVWEQRT | ||||||
Region | 912-1206 | Disordered | ||||
Sequence: PLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPE | ||||||
Compositional bias | 917-931 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAP | ||||||
Compositional bias | 934-953 | Basic and acidic residues | ||||
Sequence: LRPTARPRESARDPDARRAW | ||||||
Compositional bias | 963-1080 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQ | ||||||
Compositional bias | 1083-1100 | Polar residues | ||||
Sequence: GVPVSGPNLSTTRPIQQD | ||||||
Compositional bias | 1141-1170 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1181-1201 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Region | 1226-1260 | Disordered | ||||
Sequence: VNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPP | ||||||
Compositional bias | 1233-1253 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Domain | 1988-2022 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: STDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQN | ||||||
Region | 2029-2457 | Disordered | ||||
Sequence: QRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC | ||||||
Compositional bias | 2036-2051 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 2070-2084 | Polar residues | ||||
Sequence: SWVTQRAQEMFQKTG | ||||||
Compositional bias | 2096-2110 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2175-2194 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2245-2262 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2263-2299 | Basic and acidic residues | ||||
Sequence: APDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTH | ||||||
Compositional bias | 2300-2334 | Polar residues | ||||
Sequence: RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTP | ||||||
Compositional bias | 2440-2457 | Basic and acidic residues | ||||
Sequence: TARRGAHDAYSESEDDWC |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,457
- Mass (Da)277,603
- Last updated2019-10-16 v1
- Checksum5B8E63B102F9851A
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P97445 | CAC1A_MOUSE | Cacna1a | 2368 | ||
E9Q1R5 | E9Q1R5_MOUSE | Cacna1a | 2321 | ||
A0A571BE75 | A0A571BE75_MOUSE | Cacna1a | 183 | ||
A0A571BEF0 | A0A571BEF0_MOUSE | Cacna1a | 776 | ||
A0A1L1SQZ2 | A0A1L1SQZ2_MOUSE | Cacna1a | 2321 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 917-931 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAP | ||||||
Compositional bias | 934-953 | Basic and acidic residues | ||||
Sequence: LRPTARPRESARDPDARRAW | ||||||
Compositional bias | 963-1080 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQ | ||||||
Compositional bias | 1083-1100 | Polar residues | ||||
Sequence: GVPVSGPNLSTTRPIQQD | ||||||
Compositional bias | 1141-1170 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1181-1201 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Compositional bias | 1233-1253 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Compositional bias | 2036-2051 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 2070-2084 | Polar residues | ||||
Sequence: SWVTQRAQEMFQKTG | ||||||
Compositional bias | 2096-2110 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2175-2194 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2245-2262 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2263-2299 | Basic and acidic residues | ||||
Sequence: APDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTH | ||||||
Compositional bias | 2300-2334 | Polar residues | ||||
Sequence: RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTP | ||||||
Compositional bias | 2440-2457 | Basic and acidic residues | ||||
Sequence: TARRGAHDAYSESEDDWC |
Keywords
- Technical term