A0A564ZBA8 · A0A564ZBA8_HYMDI

Function

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionacylglycerol lipase activity
Molecular Functionhormone-sensitive lipase activity
Molecular Functionsterol esterase activity
Molecular Functiontriglyceride lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • ORF names
      WMSIL1_LOCUS14444

Organism names

  • Taxonomic identifier
  • Strain
    • WMS-il1
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Cestoda > Eucestoda > Cyclophyllidea > Hymenolepididae > Hymenolepis

Accessions

  • Primary accession
    A0A564ZBA8

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain97-207Hormone-sensitive lipase N-terminal
Domain251-416Hormone-sensitive lipase N-terminal
Compositional bias421-448Polar residues
Region421-453Disordered
Domain463-577Alpha/beta hydrolase fold-3
Region624-645Disordered
Domain785-850Alpha/beta hydrolase fold-3

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    878
  • Mass (Da)
    98,275
  • Last updated
    2019-10-16 v1
  • Checksum
    47E6F9774920CB4B
MLSFRCAKYYFIKRQLESLNGIYSTVFHFTRPLRPKMTISEPSRLSYKSKESLDRIDCESLIDLCFQVKEECRVVYQNTEVTTSPNYFLGSYVTAELHQHLAEVHQLLSETDFINQIRNIYSFARNYDFRDVRANGFRTFLSIISSCLAKILVHLRNLNRRTFSVWSKTTEESLIAYLRCLEELAFCILLICEFPKFSATPNTLFPQLAYANLPMAPFPSHDNLGPPMHISKLLVDICKLESFNTPLTSLSRYNELVDFFDLIHQDVFYGRAIAFYLDTSAQSFFRMLGSVMAGFADSYQCAMQGISGFVNAVFRSVTSFLSPEERGCRIAQITRSADVFFCKRFWSLAENRFLIEMPKLLLPQMAVSHSFDLPNEPVMLETEPIDGKSSTVTINPPLGDKGISVRLISKVRRRGMTWALSQGQEVKSSRPTLKKSPSKSSSAKSGSPSECPHVEVEPSPYLLIHIHGGGFIALSSETHDVYIRPWAEKLDCPIISLNYSLAPECPYPRALDECFHAMCWVMANRERLGARPDAQVVICGDSAGGNLSLGVCLRAAALGLKAEASRPGGALIAYAPAMLAYVPSPSRMLSICDPLLPIGIISRCIIAYNGIDEATIDRQVSEAANLNPSSKPNQERETKESQEKLPASDSVPLWLRLWSSWFPLSQSAVDPTNSPRLTPSIDRLRVVSRRFTSPCLYEIDANSISKSLPPNASFNCHPPAFSPARLTCHPSEPCINPLDFTTDAVSDEDRDKDENIENLEVPLTNSQANDTYTKVDAKLKCIRNCAIPQDPFLSPYIASDELFSLLPPLAIVACQYDPFLDDTLEIAKRADSLGVPVEVHVAAGMPHAFLNFSFLNADYRRATMQCVDMIARLFRGHT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias421-448Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABIJS010000708
EMBL· GenBank· DDBJ
VUZ56771.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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