A0A556TMS6 · A0A556TMS6_BAGYA
- ProteinDisintegrin and metalloproteinase domain-containing protein 8
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1040 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | cell adhesion molecule binding | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | inflammatory response | |
Biological Process | integrin-mediated signaling pathway | |
Biological Process | positive regulation of cellular extravasation | |
Biological Process | positive regulation of membrane protein ectodomain proteolysis | |
Biological Process | proteolysis | |
Biological Process | regulation of cell-cell adhesion |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Siluriformes > Sisoridae > Sisorinae > Bagarius
Accessions
- Primary accessionA0A556TMS6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 636-660 | Helical | ||||
Sequence: VVIIVITTIGILLVITAIFGGLIYF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MRFIGLFLLLCSYISVWEICSTAHA | ||||||
Chain | PRO_5022182356 | 26-1040 | ||||
Sequence: RLPHALRYEVVRLRTGRVKRSTFNHEKYPAAVEYSLNVNGKSFTIFLEKNRELFGNNYSLTYYTENGTKEITYPSNVDHCYYQGQIRNINDSSVSVGMCAGMRGVFRAENQVYLIEPLENSVKGDHAVYKQEHLRTKRATHGYFNDTVSDYDVAPRLAGLYNSKNKKIKVPKEGRYIEMLIVVDNTELYRPLGIRVMLVGLEVWSNQDQIDVSIAPEQTLDRFLKWRQTELLPRKKHDNAQFVTGVDFLGSTVGLAPLRSMCFPSSGAVNEDHSRSPLGIASTIAHEMGHNLGMSHDTANCDCPNTQPGQGCVMGESIGYLFPEHFSSCSKMDMETFLQNYDVRCLLNVPNEDDLFGGPLCGNAIVETGEECDCGTLEECENSCCNATTCRLTEGSECAHGECCDQCKLKQAGSLCRPSAHDCDLEEHCTGKLAHCPNDDYKMNGLPCNSNQGYCYNGQCPTNQEHCQTLWGPDADVADDVCFDNNCQWSRPSACSENKKCGTLYCSGGNEYPITQSKRFITMGRRTCNVAVDVPGTENIGMVPTGTKCGTNKVCHQSLCQDVSIYGSANCSAKCNNHGVCNHERQCHCDPGWAPPYCDNKLYDISSAQNVVIIVITTIGILLVITAIFGGLIYFKKRRPFSKKGSFKDMNGYPGQCNPTFQPVSAKNSPKCAPPRISQPTFLESSVTQSCTPIFTPITPSRAPPQANKPKPPPVPPVKASCTNPTRNPCQVSFLNINNKTVCNCPLSCAVSWLSRHRFNKLTGADLNGAQLDLCLDLQTRKKVCFMMNKELNEDALQDLYAWIDKIKLSRPKRSISRDFSDGVMAAEVVKHFFPKLVDLHNYTPAHATPQKLSNWNTLNRQANLNFHVPEDTLKKITLSNPGSIEPVLCALREKIEERQRKPLSYCTKDLECFSTENKQVKTENGLETLNENKTTSPEKKTQKSNPPIVLSENVDPGVRLLLEERGQALLSLQETVEILQAKVSRLEHLVHLKDLRIQDLTKHLEKSKARSNIP | ||||||
Disulfide bond | 441↔461 | |||||
Sequence: CRPSAHDCDLEEHCTGKLAHC | ||||||
Disulfide bond | 596↔606 | |||||
Sequence: CSAKCNNHGVC | ||||||
Disulfide bond | 614↔623 | |||||
Sequence: CDPGWAPPYC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 212-375 | Peptidase M12B | ||||
Sequence: ELYRPLGIRVMLVGLEVWSNQDQIDVSIAPEQTLDRFLKWRQTELLPRKKHDNAQFVTGVDFLGSTVGLAPLRSMCFPSSGAVNEDHSRSPLGIASTIAHEMGHNLGMSHDTANCDCPNTQPGQGCVMGESIGYLFPEHFSSCSKMDMETFLQNYDVRCLLNVP | ||||||
Domain | 383-469 | Disintegrin | ||||
Sequence: GPLCGNAIVETGEECDCGTLEECENSCCNATTCRLTEGSECAHGECCDQCKLKQAGSLCRPSAHDCDLEEHCTGKLAHCPNDDYKMN | ||||||
Domain | 592-624 | EGF-like | ||||
Sequence: GSANCSAKCNNHGVCNHERQCHCDPGWAPPYCD | ||||||
Compositional bias | 723-745 | Pro residues | ||||
Sequence: ITPSRAPPQANKPKPPPVPPVKA | ||||||
Region | 723-747 | Disordered | ||||
Sequence: ITPSRAPPQANKPKPPPVPPVKASC | ||||||
Domain | 819-922 | Calponin-homology (CH) | ||||
Sequence: EDALQDLYAWIDKIKLSRPKRSISRDFSDGVMAAEVVKHFFPKLVDLHNYTPAHATPQKLSNWNTLNRQANLNFHVPEDTLKKITLSNPGSIEPVLCALREKIE | ||||||
Region | 949-976 | Disordered | ||||
Sequence: ENGLETLNENKTTSPEKKTQKSNPPIVL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,040
- Mass (Da)116,121
- Last updated2019-10-16 v1
- Checksum4EAC3D6774AE1443
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 723-745 | Pro residues | ||||
Sequence: ITPSRAPPQANKPKPPPVPPVKA |
Keywords
- Technical term