A0A553PT02 · A0A553PT02_TIGCA

Function

function

Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionfructose 6-phosphate aldolase activity
Molecular Functionfructose-1-phosphatase activity
Molecular Functionmetal ion binding
Molecular Functionprotein-glutamate O-methyltransferase activity
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • ORF names
      TCAL_12036

Organism names

  • Taxonomic identifier
  • Strain
    • San Diego
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Hexanauplia > Copepoda > Harpacticoida > Harpacticidae > Tigriopus

Accessions

  • Primary accession
    A0A553PT02

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-307Damage-control phosphatase ARMT1-like metal-binding

Domain

Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    37,074
  • Last updated
    2019-10-16 v1
  • Checksum
    44F16C157C7E13F4
MGVRTDQGELLAPSWFQTSWLYAECYAYRRLWEAMGSTTNPKYRSLDFFEIQKQESFCGSWTSIKALIQTVEGIHKSNPKDSGSMAKNFLNLLKVSLWGNKCDLSISSGVATSFQGDPTLQVGALQPNLIVDHSRAVWDHLSANQGGIVDIILDNVGFELVSDLALADYLVSTGLAKKVRIRAKNQPWFVSDAMAHDIKWTINAMETGGDIAQNEEKTTEGKVKATDSTALREMKEKDPTLYQSLSEAQLLIFKGDLNYRKLVGDLNWDPTTSFEESLLGFHPAPLVTLRTLKADVVTSLDAGQAEELTLKDPKWMINGSWAVIKFCSRIDLI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VCGU01000001
EMBL· GenBank· DDBJ
TRY80795.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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