A0A553PH76 · A0A553PH76_TIGCA

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processbrassinosteroid biosynthetic process
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • ORF names
      TCAL_03858

Organism names

  • Taxonomic identifier
  • Strain
    • San Diego
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Hexanauplia > Copepoda > Harpacticoida > Harpacticidae > Tigriopus

Accessions

  • Primary accession
    A0A553PH76

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane13-32Helical
Transmembrane39-62Helical
Transmembrane82-103Helical
Transmembrane115-137Helical
Transmembrane202-223Helical
Transmembrane235-258Helical
Transmembrane264-285Helical
Transmembrane325-351Helical
Transmembrane357-376Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    46,925
  • Last updated
    2019-10-16 v1
  • MD5 Checksum
    B9084BF9215F8A8BAFDD5D0E3F5856F1
MNNELYVKVHQEISPPLFLAFFTLITQVLVVLGNPEAEWSILGSVFAWKVVLFFYFWGFLSLKVPGPKFYGPVSPDGDVPEYATRGTQYFLVSNLLYLSVCFFKPDLCLWIYEDFSSIIAVLNLTALALCAVLFVQAKPRPGDVGLPKMFLYYRGVELHPRILDVDVKQWTNCRVGMLGWSILVTTFCIASNLRNGFAPGPIAHAILLNLYLLKFFYWETGYFNTLDITLDRAGYYLCWGCLCWVQVFYTFCAYYLVYYPSQSTLLGSLSIVVFGLLSLTLNYMADYQKEKFKANKGRCFIWGKPAKYLEVETVGSDGRKKKSTLLLSGFWGMSRHMNYVFELMLAFTWSLPGFQLGIWPFLYFIFLLILLVHRTFRDDKKCQQKYGAGWNKYCLMVPYKMIPYVF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VCGU01000004
EMBL· GenBank· DDBJ
TRY77041.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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