A0A553PH76 · A0A553PH76_TIGCA
- Protein7-dehydrocholesterol reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids406 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | brassinosteroid biosynthetic process | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Hexanauplia > Copepoda > Harpacticoida > Harpacticidae > Tigriopus
Accessions
- Primary accessionA0A553PH76
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 13-32 | Helical | |||
Transmembrane | 39-62 | Helical | |||
Transmembrane | 82-103 | Helical | |||
Transmembrane | 115-137 | Helical | |||
Transmembrane | 202-223 | Helical | |||
Transmembrane | 235-258 | Helical | |||
Transmembrane | 264-285 | Helical | |||
Transmembrane | 325-351 | Helical | |||
Transmembrane | 357-376 | Helical | |||
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length406
- Mass (Da)46,925
- Last updated2019-10-16 v1
- MD5 ChecksumB9084BF9215F8A8BAFDD5D0E3F5856F1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VCGU01000004 EMBL· GenBank· DDBJ | TRY77041.1 EMBL· GenBank· DDBJ | Genomic DNA |