A0A550D551 · A0A550D551_9CREN

  • Protein
    Orotidine 5'-phosphate decarboxylase
  • Gene
    pyrF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site6substrate
Binding site25substrate
Active site54For OMPdecase activity
Binding site54-63substrate
Active site56For OMPdecase activity
Active site56Proton donor
Active site59For OMPdecase activity
Binding site110substrate
Binding site159-169substrate
Binding site164substrate
Binding site182substrate
Binding site183substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )

Gene names

    • Name
      pyrF
    • ORF names
      DJ522_01155

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • F3
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus

Accessions

  • Primary accession
    A0A550D551

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-198Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    23,544
  • Last updated
    2019-10-16 v1
  • Checksum
    2BD662BC5DFCB5A5
MILALDKHIPREVLLEISNEIHGIKIGLPFVLDVGLIKLKEILNDIKLEEIIIDFKLADIGFVMKQIVERLSFADAFIAHSFVGIEGALDELKTFLDSQRKNLYLVAAMSHRGWNNEFNNYIKQIIQKIEPKGIVVGATRLDTIREFRFMFPKITIISPGVGTQGANYGDAICAGGDYEIVGRSVYNSPDPINEIRKINEIIRNKVMSC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QFWC01000012
EMBL· GenBank· DDBJ
TRM85329.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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