A0A549YKL4 · A0A549YKL4_9BACI

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-15ATP (UniProtKB | ChEBI)
Binding site54UMP (UniProtKB | ChEBI)
Binding site55ATP (UniProtKB | ChEBI)
Binding site59ATP (UniProtKB | ChEBI)
Binding site74UMP (UniProtKB | ChEBI)
Binding site135-142UMP (UniProtKB | ChEBI)
Binding site163ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)
Binding site172ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • ORF names
      FH966_12385

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NKC851-2
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Lentibacillus

Accessions

  • Primary accession
    A0A549YKL4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain8-217Aspartate/glutamate/uridylate kinase
Region20-25Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    26,315
  • Last updated
    2019-10-16 v1
  • Checksum
    D3F630525C691FE7
MTTAQYRRIVLKLSGEALSGDQGYGIEPQVIQSIAAQVREVAELGVEVAVVVGGGNIWRGKVGSEMGMDRATADYMGMLATIMNSLALQDSLEKGGIPTRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMAKNNVDGVYSDDPKMNKEAEKYTEISYMQMLNKGLGVMDSTASSLCMDNDIKLIVFSIMEKGNIKRVVQGEPIGTMIRGNK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VJMZ01000001
EMBL· GenBank· DDBJ
TRM12425.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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