A0A538A7U8 · A0A538A7U8_UNCAC

  • Protein
    Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD
  • Gene
    gatD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site93Nucleophile
Binding site127substrate
Active site194

GO annotations

AspectTerm
Molecular Functioncarbon-nitrogen ligase activity on lipid II
Molecular Functionglutaminase activity
Molecular Functiontransferase activity
Biological Processcell wall organization
Biological Processcobalamin biosynthetic process
Biological Processglutamine metabolic process
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD
  • EC number
  • Alternative names
    • Lipid II isoglutaminyl synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      gatD
    • ORF names
      E6G45_13690

Organism names

Accessions

  • Primary accession
    A0A538A7U8

Proteomes

Interaction

Subunit

Forms a heterodimer with MurT.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain4-201CobB/CobQ-like glutamine amidotransferase
Region219-251Disordered
Compositional bias235-251Basic and acidic residues

Sequence similarities

Belongs to the CobB/CobQ family. GatD subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    251
  • Mass (Da)
    26,860
  • Last updated
    2019-10-16 v1
  • MD5 Checksum
    70F44EEE0E3139EDDA4E90A520B19ED7
MKLRVGHLYPDYLNIYADRGNIAVLARRAAWRGHELEVDALSVGDGVRPGEHDLLYVGGGQDREQALVADDLAAKADGLFRAMETGAALLAVCGGYQLLGRSYRDLHGADLPGVGLFPLETVAGERRMIGDVLLECELEPGVRRTLAGFENHAGRSRLDPGAVPLGRVLAGFGNDGESGEEGCRVGRAIGTYLHGPLLPRNPWFADWLLAQALAHATGEEPSELPPLPDDLEANAHAVSARRAETRGGRFS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias235-251Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VAYH01000091
EMBL· GenBank· DDBJ
TMK75388.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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