A0A536AEK4 · A0A536AEK4_UNCCH
- ProteinPutative [LysW]-L-2-aminoadipate 6-phosphate reductase
- GenelysY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids344 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
Catalytic activity
- [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP+ + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H+ + NADPH
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | N-acetyl-gamma-aminoadipyl-phosphate reductase activity | |
Molecular Function | N-acetyl-gamma-glutamyl-phosphate reductase activity | |
Molecular Function | NAD binding | |
Molecular Function | NADP+ binding | |
Biological Process | arginine biosynthetic process | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative [LysW]-L-2-aminoadipate 6-phosphate reductase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Chloroflexota
Accessions
- Primary accessionA0A536AEK4
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-136 | Semialdehyde dehydrogenase NAD-binding | ||||
Sequence: KVGIVGAAGYAGGELLRLLLGHPEVGEIVAGSESLAGKPVSAAHPNLRKRTSLSFVHYEDVTKCDVLFLSLPNGAHRAHEFEDRATVLVDLSSDHRLRDPSDYDRWYGSPHPHPDRLDRFVYGIPELRRAAIKGA | ||||||
Region | 175-194 | Disordered | ||||
Sequence: GSSEGGREPSEDSHHPERSG | ||||||
Compositional bias | 178-194 | Basic and acidic residues | ||||
Sequence: EGGREPSEDSHHPERSG |
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length344
- Mass (Da)37,218
- Last updated2019-10-16 v1
- Checksum5510B898C44ACDFB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 178-194 | Basic and acidic residues | ||||
Sequence: EGGREPSEDSHHPERSG |