A0A534VFL8 · A0A534VFL8_UNCDE

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site76substrate
Binding site204-206substrate
Binding site213Mn2+ (UniProtKB | ChEBI)
Binding site233Mn2+ (UniProtKB | ChEBI)
Binding site255substrate
Binding site256-261GTP (UniProtKB | ChEBI)
Active site257
Binding site282Mn2+ (UniProtKB | ChEBI)
Binding site372-374substrate
Binding site374GTP (UniProtKB | ChEBI)
Binding site405GTP (UniProtKB | ChEBI)
Binding site498-501GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      E6J74_01135

Organism names

Accessions

  • Primary accession
    A0A534VFL8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-224Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain229-586Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    590
  • Mass (Da)
    65,194
  • Last updated
    2019-10-16 v1
  • Checksum
    9AC0FD0783738FE3
MSVSRGTIPANPHIQKWVKEVAAMCQPDNVFWCDGSEEEKERLTQIAVECGDLIPLNQEKLPGSYLHRSALNDVARTENLTFVCTPTQEEAGPNNNWMAPAESYDKLSKIYAGSMRGRTLYVIPFLMGARGSSFSKVGIQVTDSVYVVLNMRIMTRMGKIALDHLGDSDDFTRCLHSKADLDIERRFICHYPQDNAIWSVGSGYGGNALLAKKCLALRIASKLGHQEGWLAEHMLIVGVESPDGEITYVCGAFPSACGKTNLAMLVPPATMKGWKIHTIGDDISWLRVGQDGRLWAVNPEAGCFGVAPGTGSNTNRNAMRTVTRDTIFTNVALRPDGTVWWEGHDDPVPSNALDWRGKPWDPEGGHPAAHPNARFTVSIKQCPSYSPEWEKPEGVPISAILFGARRQKMIPLVYQSFNWQHGTFLGATLASETTAAATGAVGVVRRDPMAMLPFCGYNMGDYWGHWLSMAKRATNPPKIFRVNFFQRNERGRFLWPGFGENLRVLRWIIERCKGGGQANETPIGSVPKASSLSGEGLEISKSDLDQLVAVDREAWTNNLKSQSDFFETFGDHLPAAIKEEHKALANRLKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VBKY01000015
EMBL· GenBank· DDBJ
TMA98455.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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