A0A518JVQ7 · A0A518JVQ7_9BACT

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Active site70Proton acceptor
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site154-157substrate
Binding site177substrate
Binding site182-183substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      Poly24_33380

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Poly24
  • Taxonomic lineage
    Bacteria > Planctomycetota > Planctomycetia > Pirellulales > Pirellulaceae > Rosistilla

Accessions

  • Primary accession
    A0A518JVQ7

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    22,670
  • Last updated
    2019-10-16 v1
  • Checksum
    F2D733A719FEBF80
MFELVLGTGNRKKAIEIQAVMPTDRVRLTTLADWPTAIEVVEDGNSFAENARLKSTQQAKHLGRWVLGEDSGLSVDALDGAPGIYSARFSGDDATDEKNNDLLLERLEGVPLQRRTAYYNCYLSLSDPDGNERLAANGKCCGRIIEQRHGTHGFGYDPMFEIPEYHLTFGQLGPSVKKALSHRARALRQFIPQLRLLLDQLAAQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036348
EMBL· GenBank· DDBJ
QDV69622.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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