A0A518JM92 · A0A518JM92_9BACT
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids468 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- H2O + L-histidinol + 2 NAD+ = 3 H+ + L-histidine + 2 NADH
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 278 | substrate | ||||
Sequence: S | ||||||
Binding site | 300 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 300 | substrate | ||||
Sequence: Q | ||||||
Binding site | 303 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 303 | substrate | ||||
Sequence: H | ||||||
Active site | 367 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 368 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 368 | substrate | ||||
Sequence: H | ||||||
Binding site | 401 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 401 | substrate | ||||
Sequence: D | ||||||
Binding site | 455 | substrate | ||||
Sequence: E | ||||||
Binding site | 460 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 460 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Planctomycetota > Planctomycetia > Pirellulales > Pirellulaceae > Rosistilla
Accessions
- Primary accessionA0A518JM92
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length468
- Mass (Da)49,631
- Last updated2019-10-16 v1
- ChecksumDF428416A23CB282
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP036348 EMBL· GenBank· DDBJ | QDV66669.1 EMBL· GenBank· DDBJ | Genomic DNA |