A0A517W5M5 · A0A517W5M5_9PLAN

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-16substrate
Active site73Proton acceptor
Binding site73Mg2+ (UniProtKB | ChEBI)
Binding site74substrate
Binding site157-160substrate
Binding site180substrate
Binding site185-186substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      V6x_02300

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • V6
  • Taxonomic lineage
    Bacteria > Planctomycetota > Planctomycetia > Planctomycetales > Planctomycetaceae > Gimesia

Accessions

  • Primary accession
    A0A517W5M5

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    206
  • Mass (Da)
    22,959
  • Last updated
    2019-10-16 v1
  • Checksum
    C5BF1AB3095CACEA
MSHYPRIVLASRNQKKAGEIAELLKPHGIEVQSVADFPQAQEVVEDGHSFAENAAKKAYETAQAISEWTIGEDSGLMIDALDGAPGIYSARYSGENATDEKNNAKMLEELKDVPLPERTAAYICNVALSNPQGEICLQVEARCRGRMTDQARGENGFGYDPYFEIIELHKTFGELAPIVKQHLSHRARAFERFIPQLVDLFHKLDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036347
EMBL· GenBank· DDBJ
QDU00555.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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