A0A517PIC4 · A0A517PIC4_9PLAN

  • Protein
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • Gene
    metE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site16-195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1225-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1275-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site445-447L-homocysteine (UniProtKB | ChEBI)
Binding site445-447L-methionine (UniProtKB | ChEBI)
Binding site498L-homocysteine (UniProtKB | ChEBI)
Binding site498L-methionine (UniProtKB | ChEBI)
Binding site529-5305-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5755-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site613L-homocysteine (UniProtKB | ChEBI)
Binding site613L-methionine (UniProtKB | ChEBI)
Binding site6195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site655Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site655Zn2+ (UniProtKB | ChEBI); catalytic
Binding site657Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site657Zn2+ (UniProtKB | ChEBI); catalytic
Binding site679Zn2+ (UniProtKB | ChEBI); catalytic
Binding site679Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site708Proton donor
Binding site740Zn2+ (UniProtKB | ChEBI); catalytic
Binding site740Zn2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • ORF names
      HG66A1_08900

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HG66A1
  • Taxonomic lineage
    Bacteria > Planctomycetota > Planctomycetia > Planctomycetales > Planctomycetaceae > Gimesia

Accessions

  • Primary accession
    A0A517PIC4

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-322Cobalamin-independent methionine synthase MetE N-terminal
Domain440-762Cobalamin-independent methionine synthase MetE C-terminal/archaeal

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    772
  • Mass (Da)
    86,731
  • Last updated
    2019-10-16 v1
  • Checksum
    2A050EA659EDB6B3
MAIATNLGFPRIGAQRELKRAVEKFWSGKISEAELHNVCRELRETNWKRQQQAGIAHIPSNDFSLYDQVLDTAALVGAIPRRFDWSGDEVDLATYFAMARGGKGGQSVTASTEGVAALEMTKWFDTNYHYLVPEFEGDLQFQLASRKPITEYLEAKALGIETRPVLLGPVSFLLLGKTWEADIDPLSLLDALLPVYAEVLAELAAAGAEWVQIDEPCLVLDLTEAQQAAFQRAYDRLSINGSQLKVVLATYFGDLKENLSTAVSLPVEALHIDLVRAPEQLEDVLAQLPEELSLSLGVVDGRNIWKNDVSRSISLVETVVERLGTDRVLIGPSCSLLHTPVDLSLESGLDPEVRQWLAYAQQKLEEINLITRAINGGRKSVAAELAWYDEKMESRRKSERVHRAEVKERCAGVTEEMLRRQSPYPARQTIQTHELQLPLFPTTTIGSFPQTDDIRKARAAFKKGELQEAAYEEFLKNCIASDIRCQEEIGLDVLVHGEAERNDMVEYFGEQLEGFIATKHGWVQSYGSRCVKPPVIFGDVLRKEPMTVKWTAYAQSCTEKLMKGMLTGPVTILQWSFVRDDQPRSVTCQQIGLAIRDEVLDLEASGIRVIQIDEPAIREGLPLRQADWDAYLQWAVDCFRLASAGVEDETQIHTHMCYSEFNDIIEAIGALDADVISIETSRSNMELLDAFVQYQYPNEIGPGVYDIHSPRVPTVKSIEYLLEKALEVLQPRQLWVNPDCGLKTRKWEEVKPSLENMVAAAQQLRARWLSRV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036266
EMBL· GenBank· DDBJ
QDT19126.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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