A0A517P067 · A0A517P067_9BACT

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1724100200300400500600700
TypeIDPosition(s)Description
Binding site288-295ATP (UniProtKB | ChEBI)
Binding site510Zn2+ (UniProtKB | ChEBI); catalytic
Active site511
Binding site514Zn2+ (UniProtKB | ChEBI); catalytic
Binding site587Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH4
    • Synonyms
      ftsH
    • ORF names
      K239x_47800

Organism names

Accessions

  • Primary accession
    A0A517P067

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane24-42Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region68-98Disordered
Compositional bias75-98Polar residues
Domain280-419AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    724
  • Mass (Da)
    78,866
  • Last updated
    2019-10-16 v1
  • Checksum
    18D007165B72257B
MTNKEKRPKDKDGRNGESGGGSNVWMVLIAVTTVVLLSAFLFGGNERQMRYPDLEQLLREHAKVAEVAPAADSPAADSTNAQSPAVQSPAVQSPAVQSESAPAAVPTIVVTSSKNPKVQLEYSGLENVLVADDIVTGVVNYRSLGIDGEDQAKADNKPTAVKFKSIRVRNEEQDKTLGRLLAESGVVWDNARPNRFFADHWPELLMIGVLVGLGLMMLRRIGGVGSPMQFSRSRGKLHGQEDLSITFDDAAGIDEAVEEVREVVDFLKNSEKYQALGGRIPKGVLLVGPPGTGKTLLARAIAGEAGVPFFSLSGSDFVEMFVGVGAARVRDMFQQATSRSPCIIFIDELDALGKSRSGSTVGGHDEREQTLNALLVEMDGFDANSGVIVVAATNRPETLDPALLRPGRFDRQVLVDRPDVAGREDILKVHVKHVKLDDEVDLRHIASITSGFVGADLANLVNEAALLAARAEKNTVQMEQFDDAVERVTAGLEKKNRVMNEDEKIRVAYHEAGHALVAAALPNTDPVHKVSIIPRGMAALGYTMQRPESERYLMTKTELESNMKVLLAGTLTEEMVFQDISTGAQNDLERCTEIARSMVMDYGMSRLGRINFRRSSRSPFLSGGGGGEGYQMMHGDDMAKLIDKEVARIIEESLVQTREILEQRRNVLEAVTQRLLEVESIDNTELNRLIEVNAKGPWLVPGTVTEKPLAKIRAKESDEKGKAQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias75-98Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP036526
EMBL· GenBank· DDBJ
QDT12768.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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