A0A517ME10 · A0A517ME10_9BACT
- ProteinSulfate adenylyltransferase subunit 1
- GenecysNC_2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids647 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
APS kinase catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Catalytic activity
- ATP + H+ + sulfate = adenosine 5'-phosphosulfate + diphosphate
Pathway
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | adenylylsulfate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | sulfate adenylyltransferase (ATP) activity | |
Biological Process | hydrogen sulfide biosynthetic process | |
Biological Process | sulfate assimilation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfate adenylyltransferase subunit 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Planctomycetota > Planctomycetia > Pirellulales > Pirellulaceae > Roseimaritima
Accessions
- Primary accessionA0A517ME10
Proteomes
Interaction
Subunit
Heterodimer composed of CysD, the smaller subunit, and CysN.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-237 | Tr-type G | ||||
Sequence: KQLLRFITCGSVDDGKSTLIGRLLFDSKMLYEDELSKIESDSVTQGSAGGKFDPALATDGLKEEREQGITIDVAYRYFSTAKRKFIIADTPGHEQYTRNMATGASTADLAVILIDARHGVLTQTRRHSFIVSLLGIRHVVVAVNKMDLVDFSEERFEEICRDYRAFAARLDLPDLHFIPISALNGDNVVDESPSTPWYTGSTLMNFLESVYIGSDR | ||||||
Region | 447-469 | Disordered | ||||
Sequence: TSEATGSDDGSVPNVGSEEREAR |
Sequence similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
In the C-terminal section; belongs to the APS kinase family.
In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length647
- Mass (Da)71,037
- Last updated2019-10-16 v1
- Checksum9124FC0CE5EB10A2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP036262 EMBL· GenBank· DDBJ | QDS93122.1 EMBL· GenBank· DDBJ | Genomic DNA |