A0A515L403 · A0A515L403_9STRA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • ANT105
    • ANT304
    • ANT401
    • CCMP1725
    • H3
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Ochrophyta > Bacillariophyta > Bacillariophyceae > Bacillariophycidae > Bacillariales > Bacillariaceae > Cylindrotheca

Accessions

  • Primary accession
    A0A515L403

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-54Helical
Transmembrane75-97Helical
Transmembrane117-142Helical
Transmembrane154-181Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-191Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    191
  • Mass (Da)
    20,916
  • Last updated
    2019-10-16 v1
  • Checksum
    ED2EFC794BB86253
ALSLYIRITLAQPNGSFLEYNHHFYNVIVTGHAFIMIFFMVMPILIGGFGNWFVPLMIGAPDMAFPRMNNISFWLLPPSLLLLVESVLCEAGVGTGWTVYPPLSGIIAHSGGAVDLAIFSLHLSGAASILGAINFICTIVNMRTESLPFHKLPLFVWAVFITAILLLLSLPVLAGAITMLLTDRNFNTTFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue191

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MH819220
EMBL· GenBank· DDBJ
QDM38691.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819221
EMBL· GenBank· DDBJ
QDM38692.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819222
EMBL· GenBank· DDBJ
QDM38693.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819225
EMBL· GenBank· DDBJ
QDM38696.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819228
EMBL· GenBank· DDBJ
QDM38699.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819229
EMBL· GenBank· DDBJ
QDM38700.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819230
EMBL· GenBank· DDBJ
QDM38701.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819231
EMBL· GenBank· DDBJ
QDM38702.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819232
EMBL· GenBank· DDBJ
QDM38703.1
EMBL· GenBank· DDBJ
Genomic DNA
MH819233
EMBL· GenBank· DDBJ
QDM38704.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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