A0A510J971 · A0A510J971_9ALPH

Function

function

Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Also plays a role in the primary envelopment of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Cellular Componentviral tegument
Molecular FunctionRNA binding
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tegument protein UL47

Gene names

    • Name
      UL47

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus pteropodidalpha2

Accessions

  • Primary accession
    A0A510J971

Proteomes

Subcellular Location

Cytoplasm
Host cytoplasm
Host nucleus
Virion tegument
Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.

Keywords

Expression

Keywords

Interaction

Subunit

Interacts with US3 kinase. Interacts with UL31 and UL34; these interactions seem important for efficient virion nuclear egress. Interacts with UL41/VHS.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-37Disordered
Region49-132Disordered
Compositional bias51-90Basic and acidic residues

Domain

The nuclear export signal is CRM1-dependent.

Sequence similarities

Belongs to the alphaherpesvirinae HHV-1 UL47 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    709
  • Mass (Da)
    77,225
  • Last updated
    2019-10-16 v1
  • Checksum
    7A921CEFEFB5DDCB
MSSRRNSRPQRRSIRNADAMIVDDASPMDYESADPSGAGFVGYLRSVFRFGGEDPGEEGEDRGDEPPRRRRRQSVVPAPLEDEPRRRVSRRLSGHWGSTSPDEQGVGPSLRGRRHSRRSSRPQGPAPASQIGYLGARRAAELLRLPEPLFVPSELFLQELEFEEADYKAPGPTDTAGAAKVEFLEGRLARADILDVFPLNKLFPKADVWDESLRSVVALGHPACLYPCPHRAFSLARVGDMHFASPLNPATFFRRTLQQGEELAWFLTGDSMRELTERQLQLTPHQGLSFLLDALARVAANSQACGERLHADVHANADARAGELRRQFARVAALHPLDPSSMPRLPMGGAVATQTGPAAAALRGSLGSLVYWADLRTYLDRECRVAARFAGRMTYLATSALLARIHPDTPKNILTREAAFLGRALDVLAVLAEQTIQWITLAVGAQLHPNSSLRAFKDLSLEELFRALPLGSPAVLSAEAEAMGDTATQRLIATSGLNTVLASAVFALHTALATVFIKHAQACKELRKSSEPAAARRHREEKAATRALLAAGLVFQRLLGLADTVVACLAAAAFDGGLTAPDVGAYTPLRYACVLRVARPLYSRTTPTQFWADVRAASARIHLRPVASAPPEPIAQTVEPTFLLEDLHLFPQKPLDDTSVLGPRSRVVDIMSQFRRLLMGDEDVAMLQAHLSGHRAAGLRGAPPTPSRK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias51-90Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC492974
EMBL· GenBank· DDBJ
BBM13219.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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