A0A510J971 · A0A510J971_9ALPH
- ProteinTegument protein UL47
- GeneUL47
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids709 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Tegument protein that can bind to various RNA transcripts. Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase UL41/VHS. Also plays a role in the primary envelopment of virions in the perinuclear space, probably by interacting with two nuclear egress proteins UL31 and UL34.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Cellular Component | viral tegument | |
Molecular Function | RNA binding | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTegument protein UL47
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus pteropodidalpha2
Accessions
- Primary accessionA0A510J971
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.
Keywords
- Cellular component
Expression
Keywords
- Developmental stage
Interaction
Subunit
Interacts with US3 kinase. Interacts with UL31 and UL34; these interactions seem important for efficient virion nuclear egress. Interacts with UL41/VHS.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MSSRRNSRPQRRSIRNADAMIVDDASPMDYESADPSG | ||||||
Region | 49-132 | Disordered | ||||
Sequence: RFGGEDPGEEGEDRGDEPPRRRRRQSVVPAPLEDEPRRRVSRRLSGHWGSTSPDEQGVGPSLRGRRHSRRSSRPQGPAPASQIG | ||||||
Compositional bias | 51-90 | Basic and acidic residues | ||||
Sequence: GGEDPGEEGEDRGDEPPRRRRRQSVVPAPLEDEPRRRVSR |
Domain
The nuclear export signal is CRM1-dependent.
Sequence similarities
Belongs to the alphaherpesvirinae HHV-1 UL47 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length709
- Mass (Da)77,225
- Last updated2019-10-16 v1
- Checksum7A921CEFEFB5DDCB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 51-90 | Basic and acidic residues | ||||
Sequence: GGEDPGEEGEDRGDEPPRRRRRQSVVPAPLEDEPRRRVSR |