A0A510E6L4 · A0A510E6L4_9CREN

  • Protein
    S-methyl-5'-thioadenosine phosphorylase
  • Gene
    mtnP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site16phosphate (UniProtKB | ChEBI)
Binding site58-59phosphate (UniProtKB | ChEBI)
Binding site91-92phosphate (UniProtKB | ChEBI)
Site171Important for substrate specificity
Binding site190substrate
Binding site191phosphate (UniProtKB | ChEBI)
Binding site214-216substrate
Site225Important for substrate specificity

GO annotations

AspectTerm
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      )

Gene names

    • Name
      mtnP
    • ORF names
      IC006_2727
      , IC007_2741

Organism names

  • Taxonomic identifier
  • Strains
    • IC-006
    • IC-007
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfuracidifex

Accessions

  • Primary accession
    A0A510E6L4
  • Secondary accessions
    • A0A510DYV1

Proteomes

Interaction

Subunit

Homohexamer. Dimer of a homotrimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-248Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    270
  • Mass (Da)
    30,094
  • Last updated
    2019-10-16 v1
  • Checksum
    A2B2A18DFCEB7C9D
MLEQKERASVAIIGGSGIYDLSYISDVKEIKVYTPYGSPSDLISVGRMGNVKVAFLPRHGKNHRIPPHMINYRANIWALKELGVKWVISVSAVGSLRMDYKPGDFVVPDQFIDMTKKREYTFFDGPVVAHVSMADPFCNSLRKRLIEKGNSLGIVVHGQGTYICIEGPRFSTRAESRVWKDSFKADIIGMTAVPEVNLACEAQMCYATLAMVTDYDVFADIPVTAEEVTQVMKRNTENAKKLVMEVIKDLPESPNREDCSCCSSLENALL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018929
EMBL· GenBank· DDBJ
BBG25391.1
EMBL· GenBank· DDBJ
Genomic DNA
AP018930
EMBL· GenBank· DDBJ
BBG28185.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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