A0A510E3B7 · A0A510E3B7_9CREN

  • Protein
    tRNA N6-adenosine threonylcarbamoyltransferase
  • Gene
    kae1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site109Fe cation (UniProtKB | ChEBI)
Binding site113Fe cation (UniProtKB | ChEBI)
Binding site130Fe cation (UniProtKB | ChEBI)
Binding site130-134substrate
Binding site162substrate
Binding site183substrate
Binding site262substrate
Binding site290Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular ComponentEKC/KEOPS complex
Molecular Functioniron ion binding
Molecular FunctionN(6)-L-threonylcarbamoyladenine synthase activity
Biological ProcesstRNA threonylcarbamoyladenosine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA N6-adenosine threonylcarbamoyltransferase
  • EC number
  • Alternative names
    • N6-L-threonylcarbamoyladenine synthase
      (t(6)A synthase
      )
    • t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1
    • tRNA threonylcarbamoyladenosine biosynthesis protein Kae1

Gene names

    • Name
      kae1
    • ORF names
      IC006_1526
      , IC007_1503

Organism names

  • Taxonomic identifier
  • Strains
    • IC-006
    • IC-007
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfuracidifex

Accessions

  • Primary accession
    A0A510E3B7
  • Secondary accessions
    • A0A510DVL7

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain28-297Gcp-like

Sequence similarities

Belongs to the KAE1 / TsaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    331
  • Mass (Da)
    35,763
  • Last updated
    2019-10-16 v1
  • Checksum
    D4517FAEA0D0C4E5
MLVLGIESTAHTFGVGIVRDEDPYILANERDTYVPKEGGMKPTDLLSHHASVAPSVMRSALRKASISMNDVDYIAFSMGPGIGPALRVGATVARALSLRYGKPLVPVNHGIGHIEIGFLTTKVKDPLVLYLSGGNTQIITLYKGRFRVFGETLDIALGNLMDTFSRDAGLAPPYIINGRHVIDLCAEKGNKIIDFPYVVKGQDMSYSGLLTAAENALKNNDIGDVCLTLREVAFDMLLEATERALALSGKREILIVGGVAASGSLRNKFEALGKDWGVEIKVVPSEFSGDNGAMIAYAGMLEAKAGITVDVDKSQVRPRWRVDEVEAKWRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018929
EMBL· GenBank· DDBJ
BBG24219.1
EMBL· GenBank· DDBJ
Genomic DNA
AP018930
EMBL· GenBank· DDBJ
BBG26976.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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