A0A510E3B7 · A0A510E3B7_9CREN
- ProteintRNA N6-adenosine threonylcarbamoyltransferase
- Genekae1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids331 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.
Catalytic activity
- adenosine37 in tRNA + L-threonylcarbamoyladenylate = AMP + H+ + N6-L-threonylcarbamoyladenosine37 in tRNA
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 109 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 113 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 130 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 130-134 | substrate | ||||
Sequence: YLSGG | ||||||
Binding site | 162 | substrate | ||||
Sequence: D | ||||||
Binding site | 183 | substrate | ||||
Sequence: D | ||||||
Binding site | 262 | substrate | ||||
Sequence: S | ||||||
Binding site | 290 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | EKC/KEOPS complex | |
Molecular Function | iron ion binding | |
Molecular Function | N(6)-L-threonylcarbamoyladenine synthase activity | |
Biological Process | tRNA threonylcarbamoyladenosine modification |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA N6-adenosine threonylcarbamoyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfuracidifex
Accessions
- Primary accessionA0A510E3B7
- Secondary accessions
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-297 | Gcp-like | ||||
Sequence: NERDTYVPKEGGMKPTDLLSHHASVAPSVMRSALRKASISMNDVDYIAFSMGPGIGPALRVGATVARALSLRYGKPLVPVNHGIGHIEIGFLTTKVKDPLVLYLSGGNTQIITLYKGRFRVFGETLDIALGNLMDTFSRDAGLAPPYIINGRHVIDLCAEKGNKIIDFPYVVKGQDMSYSGLLTAAENALKNNDIGDVCLTLREVAFDMLLEATERALALSGKREILIVGGVAASGSLRNKFEALGKDWGVEIKVVPSEFSGDNGAMIAY |
Sequence similarities
Belongs to the KAE1 / TsaD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length331
- Mass (Da)35,763
- Last updated2019-10-16 v1
- ChecksumD4517FAEA0D0C4E5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP018929 EMBL· GenBank· DDBJ | BBG24219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP018930 EMBL· GenBank· DDBJ | BBG26976.1 EMBL· GenBank· DDBJ | Genomic DNA |