A0A509AF89 · ARGI_PLABA
- ProteinArginase
- GeneARG
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids354 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of L-arginine into urea and L-ornithine, which is a precursor for polyamine biosynthesis (PubMed:19218089).
May play a role in parasite intra-hepatic development during the host liver stage (PubMed:20527960, PubMed:28642498).
May play a role in parasite intra-hepatic development during the host liver stage (PubMed:20527960, PubMed:28642498).
Catalytic activity
- H2O + L-arginine = L-ornithine + urea
Cofactor
Note: Binds 2 manganese ions per subunit.
Pathway
Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 136 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 159 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 159 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 161 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 163 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 165 | L-arginine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 172 | L-arginine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 217 | L-arginine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 266 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 266 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 268 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | arginase activity | |
Molecular Function | metal ion binding | |
Biological Process | arginine catabolic process to ornithine | |
Biological Process | urea cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArginase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Vinckeia)
Accessions
- Primary accessionA0A509AF89
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Mosquito salivary gland sporozoites have a reduced ability to infect BALB/c mice (PubMed:20527960).
Parasite load in the liver of C57BL/6 mouse infected with knockout sporozoites gives mixed effects; in some cases, the parasite load in the liver is not affected and in other cases, it is reduced (PubMed:28642498).
In infected BALB/c mice, causes no differences in blood parasitemia levels and in the onset of morbidity (PubMed:19218089).
Severe reduction in ornithine production during murine erythrocyte infection (PubMed:19218089).
Parasite load in the liver of C57BL/6 mouse infected with knockout sporozoites gives mixed effects; in some cases, the parasite load in the liver is not affected and in other cases, it is reduced (PubMed:28642498).
In infected BALB/c mice, causes no differences in blood parasitemia levels and in the onset of morbidity (PubMed:19218089).
Severe reduction in ornithine production during murine erythrocyte infection (PubMed:19218089).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000457082 | 1-354 | Arginase | |||
Sequence: MYECIQDYLTNHKDEKNIYVNKCISIVGSPLSAGQSLSGVNKACDNLRKFGLHDVIKAVGWGYEDIGNIGEKIPINGFLKQENIEKENDQINNNNPSYYNNIKNAEVIGKFSEKLFQTMSSELKKKNFILNIGGDHGVAFSSILSMLQTYNNLKVIWIDAHGDINIPETSPSGNYHGMSLAHALGLFKKKVPYFEWSEKLLHLKPENVAIIGIRDIDKYEKIILKKCNINYYTMFDIDKKGIYNIICEALNKIDPNKNSPIHISLDIDSVDSIYAPGTGTIAKGGLNYREIHLLIKSISDTKRVVSMDIVEYNPLLDESDKAVHGDSLPIDPNATKTGKLCLELIARVLGNDIV |
Interaction
Subunit
Homotrimer; oligomerization is dependent on Mn2+ binding.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length354
- Mass (Da)39,607
- Last updated2019-09-18 v1
- Checksum72176468A0B150AB
Keywords
- Technical term