A0A509AF62 · SUFS_PLABA
- ProteinPutative cysteine desulfurase PbSufS
- GeneSufS
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids532 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes sulfur activation and mobilization in sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis (By similarity).
Active when in complex with a partner protein SufE (By similarity).
Required for apicoplast maintenance (By similarity).
Plays a role in the development of sporozoites in oocysts in mosquitoes (PubMed:28695709).
Active when in complex with a partner protein SufE (By similarity).
Required for apicoplast maintenance (By similarity).
Plays a role in the development of sporozoites in oocysts in mosquitoes (PubMed:28695709).
Catalytic activity
- [sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanineThis reaction proceeds in the forward direction.
Cofactor
Pathway
Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 480 | Cysteine persulfide intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apicoplast | |
Molecular Function | transferase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative cysteine desulfurase PbSufS
- EC number
- Short namesPbSufS
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Vinckeia)
Accessions
- Primary accessionA0A509AF62
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Essential for blood-stage parasite survival (PubMed:24586983, PubMed:28695709).
Conditional knockout in the mosquito stages does not affect the number of oocysts and development of midgut- and salivary gland-associated sporozoites up to day 14 post-infection (PubMed:28695709).
On day 22 post-infection, fewer oocysts show sporulation and the number of salivary gland sporozoites is reduced (PubMed:28695709).
Conditional knockout in the mosquito stages does not affect the number of oocysts and development of midgut- and salivary gland-associated sporozoites up to day 14 post-infection (PubMed:28695709).
On day 22 post-infection, fewer oocysts show sporulation and the number of salivary gland sporozoites is reduced (PubMed:28695709).
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MNNESICILLLLFVKITS | ||||||
Chain | PRO_0000459467 | 19-532 | Putative cysteine desulfurase PbSufS | |||
Sequence: YYSYYISPLKKNIYTRTIYKGHILKLKNDKPEIDNNIINYFKNIRSDYPFFQQNNSPIYFDNAATTHKPKSVIEKIKNFYYYNNSNIHRGIYKISRNATDNYEHVRNIVQKYINCDSSDEIIFTSGATYGINMVCNIIMDKIIKNENDEIYISYLEHNSNIIPWQENIRNKKKGKLKYIPLKKNGYINIKKFVEKINDNTKIVSINHVSNVLGNIQNINLIIKKIKKKNPNIIVIIDAAQSFPHLKYDIKKMKLKNEDPDILVTSGHKFCAPFGSGFVYIKKKLTHTSKTNPFLYGSNIITDVNKYRSKFVSSPYIFETGTQNISAILAMGEAIKYLQKINDEGNAYKYEMYLYDLFLFYLRSFLTNHLVELPYIPEPNTPIKPDKMRTTMQVRNSKVDDKYFHSEIQNQDNDYLKIFVHNTRKDNKKKIAILPLWSLNFTSFDLVTFLDFKNICIRSGHHCASLLHNNFFNINESSRISIMFYNTPEEVQYLAEQISATTHMLHSMRRNGKAV | ||||||
Modified residue | 286 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Subunit
Monomer (By similarity).
Interacts with SufE; interaction enhances cysteine desulfurase activity of SufS (By similarity).
Interacts with SufE; interaction enhances cysteine desulfurase activity of SufS (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length532
- Mass (Da)62,332
- Last updated2019-09-18 v1
- ChecksumB20ED234B1989149
Keywords
- Technical term