A0A509AF62 · SUFS_PLABA

Function

function

Catalyzes sulfur activation and mobilization in sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis (By similarity).
Active when in complex with a partner protein SufE (By similarity).
Required for apicoplast maintenance (By similarity).
Plays a role in the development of sporozoites in oocysts in mosquitoes (PubMed:28695709).

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Cofactor biosynthesis; iron-sulfur cluster biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site480Cysteine persulfide intermediate

GO annotations

AspectTerm
Cellular Componentapicoplast
Molecular Functiontransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative cysteine desulfurase PbSufS
  • EC number
  • Short names
    PbSufS

Gene names

    • Name
      SufS
    • ORF names
      PBANKA_0614300

Organism names

  • Taxonomic identifier
  • Strain
    • ANKA
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Vinckeia)

Accessions

  • Primary accession
    A0A509AF62

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Essential for blood-stage parasite survival (PubMed:24586983, PubMed:28695709).
Conditional knockout in the mosquito stages does not affect the number of oocysts and development of midgut- and salivary gland-associated sporozoites up to day 14 post-infection (PubMed:28695709).
On day 22 post-infection, fewer oocysts show sporulation and the number of salivary gland sporozoites is reduced (PubMed:28695709).

PTM/Processing

Features

Showing features for signal, chain, modified residue.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000045946719-532Putative cysteine desulfurase PbSufS
Modified residue286N6-(pyridoxal phosphate)lysine

Expression

Developmental stage

Expressed in trophozoites (at protein level) (PubMed:24586983).
Expressed in developing liver stage parasites (PubMed:24586983).

Interaction

Subunit

Monomer (By similarity).
Interacts with SufE; interaction enhances cysteine desulfurase activity of SufS (By similarity).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    532
  • Mass (Da)
    62,332
  • Last updated
    2019-09-18 v1
  • Checksum
    B20ED234B1989149
MNNESICILLLLFVKITSYYSYYISPLKKNIYTRTIYKGHILKLKNDKPEIDNNIINYFKNIRSDYPFFQQNNSPIYFDNAATTHKPKSVIEKIKNFYYYNNSNIHRGIYKISRNATDNYEHVRNIVQKYINCDSSDEIIFTSGATYGINMVCNIIMDKIIKNENDEIYISYLEHNSNIIPWQENIRNKKKGKLKYIPLKKNGYINIKKFVEKINDNTKIVSINHVSNVLGNIQNINLIIKKIKKKNPNIIVIIDAAQSFPHLKYDIKKMKLKNEDPDILVTSGHKFCAPFGSGFVYIKKKLTHTSKTNPFLYGSNIITDVNKYRSKFVSSPYIFETGTQNISAILAMGEAIKYLQKINDEGNAYKYEMYLYDLFLFYLRSFLTNHLVELPYIPEPNTPIKPDKMRTTMQVRNSKVDDKYFHSEIQNQDNDYLKIFVHNTRKDNKKKIAILPLWSLNFTSFDLVTFLDFKNICIRSGHHCASLLHNNFFNINESSRISIMFYNTPEEVQYLAEQISATTHMLHSMRRNGKAV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LK023121
EMBL· GenBank· DDBJ
VUC54818.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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