A0A506RT15 · A0A506RT15_9ALTE

  • Protein
    Peptidoglycan D,D-transpeptidase MrdA
  • Gene
    mrdA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

163150100150200250300350400450500550600
TypeIDPosition(s)Description
Active site331Acyl-ester intermediate

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan L,D-transpeptidase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase MrdA
  • EC number
  • Alternative names
    • Penicillin-binding protein 2
      (PBP-2
      )

Gene names

    • Name
      mrdA
    • ORF names
      FJ444_05200

Organism names

  • Taxonomic identifier
  • Strain
    • GS-14
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Alteromonadaceae > Aestuariibacter

Accessions

  • Primary accession
    A0A506RT15

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein
Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-43Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain65-240Penicillin-binding protein dimerisation
Domain272-611Penicillin-binding protein transpeptidase

Sequence similarities

Belongs to the transpeptidase family. MrdA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    631
  • Mass (Da)
    71,022
  • Last updated
    2019-09-18 v1
  • Checksum
    8031F02DDAFBC250
MPIKRQTIRDHTAEANLFARRSVIAALIVIALLGMVVSNLYYLQVKHFEDYQTRSNGNRIKVVPIAPNRGLIYDRNGVLLAENRPVYNLEVIPEQVKKLDETLSELQVLMGITDEEIDDFRQALRGQRRFKPVALRARLSEEEVARFASRSHLFPGVSIEARLARFYPYGDLLTHVLGYVAKINKKDLQKIKEAGLEANYAATYDIGKLGIEKYHEDILHGKVGFQQVEVNSQGRIIRTLNVDPPEPGRDIVLNIDIRLQQAAQQALEGQRGTVVLASPHTGGILAMYSNPSYDPNLFVHGISRKNYADLLNSPDRPLINRATQGQYPPASTVKPLLALLSLETDTIDKSFKINDNGRYSLPNVSHVWRDWKKWGHGEVDVTRSIEMSCDTFYYELAYQMGIDLISDYMSEFGFGDYTGIDLYEESDANMPSRGWKKARYNQPWYIGDTISVGIGQGYWTTTPIQLVHAMNALVNYGARFVPQILRGYYQPGGDVELEPLKSLRPIEINNQDNWEIVLDAMYGTVNREHGTARTAFVGTTYTAAGKTGTAQLFSVGQNEKYDAKKIDERLRDNAMYVGFAPYENPEITVAVVMENAGGGSSNAAPIARIMMDEFFRLHPEAIKYPKAVKAN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VHIP01000002
EMBL· GenBank· DDBJ
TPV61016.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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