A0A504XIM8 · A0A504XIM8_LEIDO
- ProteinFanconi-associated nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1690 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | phosphodiesterase I activity | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi-associated nuclease
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionA0A504XIM8
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-30 | Disordered | ||||
Sequence: MSADADASPTDPFLNSRSTEASRSRADNDG | ||||||
Region | 87-187 | Disordered | ||||
Sequence: AAAIMHHSRKRERPAVALASAGSSTSTTAAPPLAQRRRIAGQRKSGATPSSSRRAGGAARTIVDRGQHSTKDRSDEDELAEGAGGEYCSDNEEGYAPDDGV | ||||||
Compositional bias | 151-166 | Basic and acidic residues | ||||
Sequence: RGQHSTKDRSDEDELA | ||||||
Region | 681-703 | Disordered | ||||
Sequence: QARPSLTEPSPSTAAHPDPKAFK | ||||||
Region | 742-768 | Disordered | ||||
Sequence: GGRAANKTESRSRPDASAEPSDNDSSL | ||||||
Region | 1205-1237 | Disordered | ||||
Sequence: EPSGQAPGRPSTSAGGAAEAAKSTTPSGALHPQ | ||||||
Region | 1263-1297 | Disordered | ||||
Sequence: TAAAANAATDPKPRRRKGTLTANSAKAETEGRDNA | ||||||
Region | 1419-1483 | Disordered | ||||
Sequence: TAEGVGPSNLKARRRDAGAEAPRKEAHVVQRADEDKGYDRDEERARRRRSRDEYGCGPHRHSYTA | ||||||
Compositional bias | 1427-1483 | Basic and acidic residues | ||||
Sequence: NLKARRRDAGAEAPRKEAHVVQRADEDKGYDRDEERARRRRSRDEYGCGPHRHSYTA | ||||||
Domain | 1566-1676 | VRR-NUC | ||||
Sequence: LPLLDILRAIPLEPLWRLLRCLYLSPVTEGVPLAFSGFPDLVFWRTGGSGGGECSNAALQPSVGGDSAVLRTSFCLMEVKGPSDFLSTKQIAVNDLLHRCGFEVCVVRVDE |
Sequence similarities
Belongs to the FAN1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,690
- Mass (Da)182,961
- Last updated2019-09-18 v1
- Checksum2F92FAA01D894955
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 151-166 | Basic and acidic residues | ||||
Sequence: RGQHSTKDRSDEDELA | ||||||
Compositional bias | 1427-1483 | Basic and acidic residues | ||||
Sequence: NLKARRRDAGAEAPRKEAHVVQRADEDKGYDRDEERARRRRSRDEYGCGPHRHSYTA |