A0A504XIM8 · A0A504XIM8_LEIDO

  • Protein
    Fanconi-associated nuclease
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionphosphodiesterase I activity
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • ORF names
      CGC21_13665

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FDAARGOS_361
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    A0A504XIM8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-30Disordered
Region87-187Disordered
Compositional bias151-166Basic and acidic residues
Region681-703Disordered
Region742-768Disordered
Region1205-1237Disordered
Region1263-1297Disordered
Region1419-1483Disordered
Compositional bias1427-1483Basic and acidic residues
Domain1566-1676VRR-NUC

Sequence similarities

Belongs to the FAN1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,690
  • Mass (Da)
    182,961
  • Last updated
    2019-09-18 v1
  • Checksum
    2F92FAA01D894955
MSADADASPTDPFLNSRSTEASRSRADNDGAMVVEVVDDCQTASSSSAAPAAPFATRVRPSTIVARGESPQEAMTHLANNAAASTSAAAIMHHSRKRERPAVALASAGSSTSTTAAPPLAQRRRIAGQRKSGATPSSSRRAGGAARTIVDRGQHSTKDRSDEDELAEGAGGEYCSDNEEGYAPDDGVEGDAEERALVSASIALMAGQGALTAPSAASATPHLWLVTDAFHVCLWYVLRYAGRALSAEDLWACRALLSLTAVDATEEEDGGERATAPFAAAQARSANMHFDDWAWSGSEESELLLRLLLRHAHGFTARHLELRYGDWLHVQPALNALTQRRFLWWATKQASLDSAGGGAETVCLHSAEEDASTDLTETPLLPADELARTEMASSPLVEHYDGARVARLLLSCCEEGRPQHRHATAVSKSASSFSSVETVIRVAQAVRATELRTFLTTLRHCSKARALMDERARGGDATITTRAIAFTTASTLGTSGNALCKDGSSGGGVMAEPTPVLRLKSSGWTDDVACARPGQISHNSLYDVIPGRKRDMIRYLVERRYSVWVPTSTVNGSPAAAFASAPDRSPFRRCFPTVSVESDAVAQCWDRVIGSVYVPHSGLRQHLTWITELFHVLTSNNGAGMVSGQGAKAVMATMTVATPPTLLMVRPQLLLLLQTLRAARHQARPSLTEPSPSTAAHPDPKAFKESVPHALLPQWCSPPPVVKATKVALPRVCGQLYRDISSGGRAANKTESRSRPDASAEPSDNDSSLMDTIVHTSRSFRDFGAAEDGTVTQVWPTPPHVCLFSSPATLQEYRRALSTQRELYCVTEGAVTAAQRHRGKSSAFVSHMYDTVMAAVRAGVAAVKQHPHHARTAASASLVSGKVTHFGSMHPPAPPVVSEAAPLSKHFTQSVTASLESLVYHQGCHAEHLLIFTPLYRWFACLELLFPLLQSARRYDDANACLHHLLYEPIFVLHHMPVSGARCHISPITYEFRYKPHKRGKWVARLAQNLSHQKRYAEAFAVLEEAQAGYRELASHTADDARSVPATGSDGGGHVTNDKWLPCDAMSNSTAAALCNVLAGNHSPASESALPIKVQRRSRMLRVLWPAAASATFATDDNNSSPPAAEGLSPASLALLHAAWEYVRDRYCRRQDRLTLERLLAVTHRKVRQWTPPAAYLEFATRRLVDVAMRHIGGVRDKLDRMLWREPSGQAPGRPSTSAGGAAEAAKSTTPSGALHPQRRPALPVELLVLQRYLSRWNGASRTTAAAANAATDPKPRRRKGTLTANSAKAETEGRDNAGGAKVTSVWCGVHCEGQWIACLARALLWDCYWAFPSVSPPFASFPVSAGDHESDQPPLQTCSTHEVLWLSAFQDGPLDLTTPIQFLWRRRALIEARLAQLERCTREELIAYVGARIKVEGNTAEGVGPSNLKARRRDAGAEAPRKEAHVVQRADEDKGYDRDEERARRRRSRDEYGCGPHRHSYTAKMEEEFRGSNEEDSVQIASSLPATPLLSTGSETSSLVLGRVVQERNAEAQRVESVKDSADASLSSRVSTLAVPEAWKVPVGPLPLLDILRAIPLEPLWRLLRCLYLSPVTEGVPLAFSGFPDLVFWRTGGSGGGECSNAALQPSVGGDSAVLRTSFCLMEVKGPSDFLSTKQIAVNDLLHRCGFEVCVVRVDEVYDDGQRVSTKRIR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias151-166Basic and acidic residues
Compositional bias1427-1483Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RHLC01000054
EMBL· GenBank· DDBJ
TPP48383.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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